Ukr.Biochem.J. 2012; Volume 84, Issue 5, Sep-Oct, pp. 89-96

Antioxidant and cerebroprotective action of N-,S-chinazolone derivative under rat brain ischemiа

Yu. I. Gubsky1, I. F. Belenichev2, С. І. Kovalenko2,
G. G. Goryushko1, N. V. Buhtiayrova2, N. V. Litvinova1,
V. C. Nikitin2, C. V. Pavlov2, L. P. Babenko1

1SI Institute of Pharmacology and Toxicology,
National Academy of Medical Sciences of Ukraine, Kyiv;
2Zaporizhzhia State Medical University, Ukraine;

Under modelling of brain ischemia in rats the antioxidant and cerebroprotective action of new N-,S-chinazolone derivative – compound NC-224 has been established. The compensation of pathobiochemical abnormalities in the system “LPO-antioxidant protection” is observed, indicators of carbohydrate metabolism and energy-supply, and morpho-functional status of brain cells are improved under administration of the compound NC-224. Administration of the compound NC-224 to rats promoted a decrease of the lethality index and signs of neurological deficiency.

Keywords: , , , ,

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