Ukr.Biochem.J. 2011; Volume 83, Issue 5, Sep-Oct, pp. 22-31

Activation of the phosphatidylinositol-3′-kinase pathway with lectin-induced signal through sialo-containing glycoproteins of leukocyte membranes under type 1 diabetes mellitus

N. Sybirna1, М. Zdioruk1, І. Brodyak1, M. Bars’ka2, О. Vovk2

1Ivan Franko National University of Lviv, Ukraine;
2Institute of Cell Biology, National of Academy of Sciences of Ukraine, Lviv;

The influence of wortmannin and sialospecific lectins on the translocation of p85α regulatory subunit of phosphatidylinositol-3′-kinase (PI-3′-kinase) between membrane and cytosolic fractions of the mononuclear and polymorphonuclear leukocytes in healthy donors and patients with type 1 diabetes mellitus (DM) was investigated. It was found out that under type 1 DM PI-3′-kinase takes active part in the transduction of lectin-induced signal through membrane glycoprotein receptors that contain terminal sialic acids linked to subterminal carbohydrate residues with (α2→6) glycosidic bond.

Keywords: , , , , , ,

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