Ukr.Biochem.J. 2018; Volume 90, Issue 6, Nov-Dec, pp. 110-119
doi: https://doi.org/10.15407/ubj90.06.110
The effect of intranasally administered TLR3 agonist larifan on metabolic profile of microglial cells in rat with C6 glioma
Y. Hurmach1, M. Rudyk1, V. Svyatetska1, N. Senchylo1,
O. Skachkova2, D. Pjanova3, K. Vaivode3, L. Skivka1
1ESC Institute of Biology and Medicine, Taras Shevchenko National University of Kyiv, Ukraine;
2Research Laboratory of Experimental Oncology, National Cancer Institute, Kyiv, Ukraine;
3Latvian Biomedical Research and Study Centre, Riga, Latvia;
e-mail: jhurmach@gmail.com
Glioma-associated microglia/macrophages (GAM) represent an attractive therapeutic target for the development of the alternative methodology in the treatment of gliomas. This study was aimed to investigate the effect of intranasally administered TLR3 agonist Larifan on microglial cell metabolic profile in rats with C6 glioma. Our results demonstrate progressive generation microglial cell population with immunosuppressive and pro-inflammatory properties in C6 glioma-bearing brain. Intranasally delivered TLR3 agonist is capable to abrogate the creation of this pro-tumoral immune infiltrates, probably, through the effect on myeloid-derived suppressor cells, and can be considered as a promising agent for glioma therapy aimed the GAM re-education.
Keywords: glioma, immunotherapy, microglia, toll-like receptor agonist
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