Alaa Salman (https://orcid.org/0009-0002-0236-3692)

Ishtar Medical Technical Institute, Iraq;
e-mail: alaas3223@gmail.com

Received: 22 March 2026; Revised: 21 April 2026;
Accepted: 29 May 2026; Available on-line: June 2026

Background. Cardiovascular system is particularly responsive to fluctuations in thyroid hormone levels and hypothyroid patients are at an increased risk of worse cardiovascular outcomes. N-terminal pro-B-type natriuretic peptide (NT-proBNP) is a recognised biomarker for heart failure. Several studies indicate that thyroid disorders may influence blood NT-proBNP level, nevertheless, a consensus has not been established. Objective. To investigate the impact of the single nucleotide polymorphism rs198389 in NT-proBNP gene on the NT-proBNP serum level in patients with untreated primary hypothyroidism. Methods. The study included 100 newly diagnosed hypothyroid patients and 100 healthy controls, with NT-proBNP level measu­red with enzyme-linked fluorescent assay and genetic analysis conducted via PCR. Results. Our findings indicated significantly elevated NT-proBNP level across all genotypes (CC, CT, TT) in hypothyroid patients compared to controls. This elevation correlated strongly with thyroid-stimulating hormone level. Conclusions. The study demonstrated that NT-proBNP can discriminate between hypothyroid patients and healthy controls, but further studies are needed to establish its role in cardiovascular risk prediction.

Keywords: correlation analysis, hypothyroidism, NT-proBNP, single nucleotide polymorphisms, thyroid-stimulating­ hormone