L. A. Gromov¹, I. F. Belenichev², L. G. Gonchar-Cherdakli¹, G. A. Zhernovaja²

¹SI Іnstitute of Pharmacology and Toxicology, National Academy of Medical Sciences of Ukraine, Kyiv;
²Zaporizhia State Medical University, Ukraine;
e-mail: llrr@ukr.net

The effect of phenobarbital, carbamazepine, valproate sodium, depakine, topiramate and lamotrigine on the content of NO and NO-synthase activity in white rat brain tissues has been studied. It was established that the action of carbamazepine, valproate sodium, topiramate and lamotrigine decreases the activity of NO-synthase and the level of NO in the brain tissues. The amount of NO does not change while NO-synthase activity increases with the introduction of phenobarbital. The involvement of nitric oxide in the mechanism of action of the studied anticonvulsant drugs is discussed.