N. V. Zaichko¹, A. S. Olhovskiy¹, A. V. Melnik¹,
P. A. Yurchenko¹, A. S. Grigorieva², N. F. Konahovich²

¹Pirogov Vinnitsa National Medical University, Ukraine;
²SI Institute of Pharmacology and Toxicology,
Academy of Medical Sciences of Ukraine;
e-mail: nzaichko@mail.ru

The influence of microelement preparation Esmin on hydrogen sulfide (H₂S) levels, activity of H₂S -producing enzymes and indices of pro-/antioxidant system in the myocardium of different age rats were investigated. In the process of aging the levels­ of H₂S and activities of H₂S-producing enzymes (cysteine aminotransferase, cystathionine-γ-lyase) are reduced in the myocardium; the pro-/antioxidant balance is destabilized (NADPH-oxidase activity is increased and thioredoxin reductase activity is decreased). Esmin administration effectively reduces age-related changes in the myocardium of old rats: increases H₂S levels and activity of H₂S-producing enzymes, restores pro-/antioxidant balance.