Tag Archives: prolife­ration

Folate-related processes in human placenta: gene expression, aminothiols, proliferation and apoptosis

M. Yu. Obolenskaya, R. R. Rodriges, O. P. Martsenyuk

Institute of Molecular Biology and Genetic, National Academy of Sciences of Ukraine, Kyiv;
e-mail: m.obolenska@gmail.com

The paper contains short information concerning the role of folate-related processes in cell metabolism and multiple diseases which are characterized by hyperhomocysteinemia. The authors represent more detailed information about the folate-related processes in human placenta, namely about the content of aminothiols at different allelic variants of placental methylenetetrahydrofolate reductase during the course of physiological pregnancy and preeclampsia. The existing data concerning the expression and catalytic activi­ty of corresponding enzymes are corroborated by the authors’ own results that proved for the first time the functional activity of transsulfuration pathway in human placenta. This pathway is activated in placental explants in parallel with down-regulation of proliferation and up-regulation of apoptosis when hyperhomocystei­nemia is imitated by high concentration of homocysteine in culture medium. On the whole the presented data point to the importance of placental folate-related processes for its normal function.

Role of multidomain structure of urokinase in regulation of growth and remodeling of vessels

V. A. Tkachuk1,2, O. S. Plekhanova1, I. B. Beloglazova1, E. V. Parfenova1

1Russian Cardiologic Research-Production Complex,
RF Ministry of Public Health, Moscow, Russia;
2Faculty of Fundamental Medicine, M.V. Lomonosov Moscow
State University, Russia;
e-mail: plekhanova@mail.ru

Urokinase type plasminogen activator, or urokinase (uPA), is a multifunctional protein which plays special regulatory role in the vascular wall and can actuate the proteolytic and signal cascades. The authors’ results and literature data concerning the role of urokinase in remodeling blood vessels and angiogenesis are summarized in the paper. At the present stage urokinase may be conside­red as a promising target for the effects directed to prophylaxis of restenoses, to preventing of negative remodeling of arteries­, stimulation of vessels growth under the ischemic diseases and suppression of angiogenesis under oncologic diseases.