Ukr.Biochem.J. 2015; Volume 87, Issue 2, Mar-Apr, pp. 95-102

doi: https://doi.org/10.15407/ubj87.02.095

Antioxidant activity of alkoxy derivatives of (quinoline-4-ylthio)carboxylic acids

29.05.2015   Uncategorized   No comments

O. О. Brazhko1, M. P. Zavgorodny1, O. S. Kruglyak2,
L. O. Omeljanchik1, G. A. Shapoval2

1Zaporizhzhya National University, Ukraine;
2Institute of Bioorganic Chemistry and Petrochemistry,
National Academy of Sciences of Ukraine, Kyiv;
e-mail: hellen.brazhko@gmail.com

A selection of potential bioactive molecules including alkoxy derivatives of (quinoline-4-ylthio)carboxylic acids using virtual screening has been carried out and their biological activity was determined. The studied substances proved to be low-toxic, biologically active compounds. It was established that 4-thio derivatives of quinoline exhibit pronounced antiradical, antioxidant effects and can act as preventive antioxidants, radio and cytoprotectors.

Keywords: , , , ,

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