Ukr.Biochem.J. 2017; Volume 89, Issue 2, Mar-Apr, pp. 121-134

doi: https://doi.org/10.15407/ubj89.02.121

Scientific and practical activity of the Department of Neurochemistry of the Palladin Institute of Biochemistry of NAS of Ukraine

24.04.2017   Uncategorized   No comments

V. M. Danilova, R. P. Vynogradova, G. G. Lugovska

Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv;
e-mail: valdan@biochem.kiev.ua

The article analyzes the scientific and practical activity of the Department of Neurochemistry (formerly called the Department of Biochemistry of the nervous system) of the Palladin Institute of Biochemistry of NAS of Ukraine in the context of the history of its development. The most important achievements in decoding the biochemical fundamentals of physiological functions of the nervous system that can be useful for solving some problems of clinical medicine are presented and discussed.

Keywords: , ,

References:

  1. Department of Nervous System Biochemistry. Palladin Institute of Biochemistry. K.: Nauk. dumka, 1975; 112-131. (In Russian).
  2. Lishko VK, Himmelreich NG. Department of Neurochemistry. Ukr Biokhim Zhurn. 1995 May-Jun;67(3):8-22. (In Ukrainian). PubMed
  3. Himmelreich NH. Department of Neuro­chemistry. Palladin Institute of Biochemistry of National Academy of Sciences of Ukraine – 80 (1925–2005). Executive Ed. S.V. Komisarenko. K.: Alfa-Praym, 2005: 54-73. (In Ukrainian).
  4. A.C. 67601 SU, IPC6 A 61 K 31/122, A 61 P 7/04. Method to stop bleeding and accelerate wound healing. Palladin OV. (USSR), No 3659; appl. 19.09.42; publ. 15.10.46. (In Russian).
  5. Rashba OIa. Biochemistry of nervous system. Popular science essay. Publ. Academy of Sciences of UkrSSR. K.: 1952; 72. (In Ukrainian).
  6. Khaikina BI, Goncharova KO. Enzyme synthesis of brain polysaccharides. Ukr Biokhim Zhurn. 1949; 21(3): 239-246. (In Ukrainian).
  7. Khaikina BI, Goncharova KO. Brain phosphorylase at insulin intoxication. Ukr Biokhim Zhurn. 1950; 22(1): 92-100. (In Ukrainian).
  8. Palladin OV, Khaikina BI. Glicogen in animal brain. Ukr Biokhim Zhurn. 1950; 22(4): 462-470. (In Ukrainian).
  9. Kurskiy MD. Serotonin and metabolism in the animal organism. Usp Sovrem Biol. 1969 Mar-Apr;67(2):190-200. (In Russian). PubMed
  10. Kudinov SA. Transport systems of Ca2+ in nerve cells. K.: Nauk. dumka, 1983; 160 p. (In Russian).
  11. Palladin OV. Nervous system proteins and their metabolism. In: Actual problems of modern biochemistry. V. 1: Biochemistry of proteins. M.: 1959; 102-113. (In Russian).
  12. Poliakova NM. Proteins of the nervous system. Ukr Biokhim Zhurn. 1960;32(1):120-128. (In Russian).
  13. Palladin OV. Proteins of the nervous system, their metabolism and role in nervous activity. In: Problems of neurochemistry. M.-L.: Nauka, 1966; 5-17. (In Russian).
  14. Terletska IaT, Belik IaV, Kozulina OP, Syrovatska LP, Gershkovych OA, Kibirev VK, Serebrianyi SB. The effectiveness of treatment of guinea pig with experimental allergic encephalomyelitis by myelin basic protein and synthetic encephalitogenic nanopeptide. Dopov AN UkrSSR. Ser. B. 1976; 10: 934-937. (In Ukrainian).
  15. Palladin AV. Basis of the biochemistry of memory. Ukr Biokhim Zhurn. 1971 Sep-Oct;43(5):653-64. (In Russian). PubMed
  16.  Palladin AV, Belik IaV, Poliakova NM. Brain proteins and their metabolism. K.: Nauk. Dumka, 1972; 316 p. (In Russian).
  17. Smerchinskaia LS, Belik IaV, Syrovatskaia LP, Birillo TN. Heterogeneity of neurospecific protein S-100. Ukr Biokhim Zhurn. 1976 Sep-Oct;48(5):609-14. (In Ukrainian).
    PubMed
  18. Aleksidze NG, Berezhnoi GA. Nikuradze VO, Belik IaV. The question of specificity of the protein S-100 in learning and memory. Neirokhimiya. 1982; (1): 43-50. (In Russian).
  19. Syrovatskaia LP, Kozulina EP, Terletskaia IaT, Belik IaB. Immunological identity of neurospecific (SCP and P-2) proteins and SCP protein distribution in the nervous system. Ukr Biokhim Zhurn. 1979 Nov-Dec;51(6):647-52. (In Russian). PubMed
  20. Berezin VA, Belik YaV. Specific proteins of nerve tissue. K.: Nauk. dumka, 1990; 264 p. (In Russian).
  21. Lishko VK. Sodium pump in biological membranes. K.: Nauk. dumka. 1977; 144 p. (In Russian).
  22. A.C. 1289440 SU, IPC4 A23C 17/00; 7/00; A 61 K 37/22. Method for obtaining phospholipids. Melnichuk DA., Lishko VK., Stefanov AV., Kirilenko VN., Zhukovskiy NI., Skorik LV., (USSR). No 3846599; appl. 23.01.85; publ. 15.02.87. Bul. No 6. (In Russian).
  23. A.C. 1424167 SU, IPC4 A 61 K 9/52, 31/685. Method for obtaining liposome. Stefanov AV., Bryginskiy SA., Zubarenko AV., Lishko VK., Miniaylenko TD., Pozharov VP., Rozova IeV., Seredenko MM. (USSR), No 4055902; appl. 14.04.86. restr., 1988. (In Russian).
  24. Pozharov VP, Miniaylenko TD, Stefanov AV, Bryginskiy SA, Seredenko MM, Lishko VK. The physiological mechanisms of the antihypoxic action of the liposomes. Fiziol Zh SSSR Im I M Sechenova. 1990 Jul;76(7):897-902. (In Russian). PubMed
  25. Stefanov AV, Pozharov VP, Miniaylenko TD, Bryginskiy SA, Seredenko MM, Lishko VK. Biological effect of liposomes in hypoxic conditions of various etiologies. Vestn Akad Med Nauk SSSR. 1990;(6):47-51. (In Russian). PubMed
  26. A.C. 1818734 SU, IPC5 A 61 K 31/66. Method for prophylaxis and treatment of hypoxia in experiments. Stefanov AV., Bryginskiy SA., Lishko VK., Pozharov VP., Miniaylenko TD., Zubarenko AV., Seredenko MM., Rozova IeV., Kondratiuk VI., Iukhimets VA., Radionov BV., Linnik NI. (USSR). No 4423608; appl. 10.05.88, restr. 1992. (In Russian).
  27. A.C. 1550669 SU, IPC5 A 61 K 47/00. Method for obtaining liposome with antimetastasis properties. Stefanov AV., Bondar OP., Umanskiy VIu., Kondratiuk VI., Lishko VK., Balitskiy KP., Pinchuk BG. (USSR); appl. 12.02.88, restr. 1988. (In Russian).
  28. Krisanova N, Sivko R, Kasatkina L, Borisova T. Neuroprotection by lowering cholesterol: a decrease in membrane cholesterol content reduces transporter-mediated glutamate release from brain nerve terminals. Biochim Biophys Acta. 2012 Oct; 1822(10): 1553-61.  PubMed, CrossRef
  29. Pat. 22875 Ukraine, IPC (2006) A61K 47/12, C07C 2500. Compound 3-decyloxycarbonylmethyl-4-methyl-5-(2-hydroxyethyl) thiazole chlori­de, which exhibits a blocking effect on ionic conduction in channels formed by amphotericin B. Romanenko OV, Vovk AI, Gimmelreikh NG, Shaturskiy OIa. Applicants and patent owners: Bogomolets National Medical University; Palladin Institute of Biochemistry, NAS of Ukraine; Institute of Bioorganic Chemistry and Petrochemistry, NAS of Ukraine, No u200614003; appl. 28.12.2006; publ. 25.04.2007, Bul. No 5. (In Ukrainian).
  30. Pat 27417 Ukraine, IPC (2006) 8 C07D 277/00. Compound 3-decyloxycarbonylmethyl-4-methyl-5-(2-hydroxyethyl) thiazole chloride, which exhibits a blocking effect on ionic conduction in channels formed by nystatin. Shaturskiy OIa, Romanenko OV, Vovk AI, Gimmelreikh NG. Applicants and patent owners: Palladin Institute of Biochemistry, NAS of Ukraine; Bogomolets National Medical University; Institute of Bioorganic Chemistry and Petrochemistry, NAS of Ukraine, No u 200707806; appl. 11/07/2007; publ. 25.10.2007, Bul. No 17. (In Ukrainian).
  31. Pat. 38155 UA (51) IPC (2006) C 07D 277/00. Compound 3-decyloxycarbonylmethyl-4-methyl-5-(2-hydroxyethyl) thiazole chloride, which exhibits inhibitory effect on the sodium-dependent glutamate accumulation by isolated nerve terminals. Borisova TO, Krisanova NV, Sivko RV, Romanenko OV, Vovk AI. Applicants and patent owners: Bogomolets National Medical University; Palladin Institute of Biochemistry, NAS of Ukraine; Institute of Bioorganic Chemistry and Petrochemistry, NAS of Ukraine. No u 200809322; appl. 17.07.2008; publ. 25.12.2008, Bul. No 24. (In Ukrainian).
  32. Pat. 45942 UA (51) IPC (2009) C07D 277/00. Application of 3-decyloxycarbonylmethyl-4-methyl-5-(2-hydroxyethyl) thiazole chloride as compound that causes an increase in unstimulated release of glutamate from the nerve terminals of rat brain. Borisova TO, Romanenko OV, Krisaniva NV, Sivko RV, Borisov AA, Vovk AI. Applicants and patent owners: Bogomolets National Medical University; Palladin Institute of Biochemistry, NAS of Ukraine; Institute of Bioorganic Chemistry and Petrochemistry, NAS of Ukraine. No u200909718; appl. 23.09.2009; publ. 25.11.2009, Bul. No. 22. (In Ukrainian).
  33. Pat. 45941 UA (51) IPOC (2009) C07D 277/00. Application of 3-decyloxycarbonylmethyl-4-methyl-5-(2-hydroxyethyl) thiazole chloride as compound that causes plasma membrane depolarization in isolated rat brain nerve terminals. Borisova TO, Romanenko OV, Ostapchenko LI, Kasatkina LO, Krisanova NV, Borisov AA, Vovk AI. Applicants and patent owners: Bogomolets National Medical University; Palladin Institute of Biochemistry, NAS of Ukraine; Institute of Bioorganic Chemistry and Petrochemistry, NAS of Ukraine. No u200909717; appl. 23.09.2009; publ. 25.11.2009, Bul. No 22. (In Ukrainian).
  34. Pat. 45943 UA (51) IPC (2009) C07D 277/00. Application of 3-decyloxycarbonylmethyl-4-methyl-5-(2-hydroxyethyl) thiazole chloride as compound that causes decrease in synaptic vesicle proton gradient in isolated rat brain nerve terminals. Borisova TO, Romanenko OV, Ostapchenko LI, Kasatkina LO, Krisanova NV, Borisov AA, Vovk AI. Applicants and patent owners: Bogomolets National Medical University; Palladin Institute of Biochemistry, NAS of Ukraine; Institute of Bioorganic Chemistry and Petrochemistry, NAS of Ukraine. No u200909719; appl. 23.09.2009; publ. 25.11.2009, Bul. No 22. (In Ukrainian).
  35. Pat. 48769 UA (51) IPC (2009) C07D 277/00. Application of 3-decyloxycarbonylmethyl-4-methyl-5-(2-hydroxyethyl) thiazole chloride as compound that causes plasma membrane depolarization in thrombocytes from rabbit blood. Borisova TO, Romanenko OV, Kasatkina LO, Borisov AA, Vovk AI. Applicants and patent owners: Bogomolets National Medical University; Palladin Institute of Biochemistry, NAS of Ukraine; Institute of Bioorganic Chemistry and Petrochemistry, NAS of Ukraine. No u200913467; appl. 24.12.2009; publ. 25.03.2010, Bul. No 6. (In Ukrainian).
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