M. A. Stashkevych, E. V. Khomutov, O. P. Shatova, Yu. V. Dumanskiy, I. I. Zinkovych

M. Gorky Donetsk National Medical University, Ukraine;
e-mail: matviyenko.maryna@gmail.com

In blood plasma of 8 healthy volunteers with resuspended lymphocytes incubated with 5-fluorou­racil (5-FU) the drug distribution between cells and liquid was assessed by means of HPLC. Rapid accumulation of 5-FU in lymphocytes was proved (the drug concentration on the 3-rd minute is 2.5-fold higher than in plasma) as well as the absence of temporal changes of 5-FU content both in lymphocytes and blood plasma during 30 minutes of experiment.