Ukr.Biochem.J. 2013; Volume 85, Issue 4, Jul-Aug, pp. 94-97

doi: http://dx.doi.org/10.15407/ubj85.04.094

Distribution of 5-fluorouracil between lymphocytes and blood plasma

28.10.2015   Uncategorized   No comments

M. A. Stashkevych, E. V. Khomutov, O. P. Shatova, Yu. V. Dumanskiy, I. I. Zinkovych

M. Gorky Donetsk National Medical University, Ukraine;
e-mail: matviyenko.maryna@gmail.com

In blood plasma of 8 healthy volunteers with resuspended lymphocytes incubated with 5-fluorou­racil (5-FU) the drug distribution between cells and liquid was assessed by means of HPLC. Rapid accumulation of 5-FU in lymphocytes was proved (the drug concentration on the 3-rd minute is 2.5-fold higher than in plasma) as well as the absence of temporal changes of 5-FU content both in lymphocytes and blood plasma during 30 minutes of experiment.

Keywords: , , ,

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