Tag Archives: plasma
The effect of agmatine on L-arginine metabolism in erythrocytes under streptozotocin-induced diabetes in rats
I. V. Ferents, I. V. Brodyak, M. Ya. Lyuta,
V. A. Burda, A. M. Fedorovych, N. O. Sybirna
Ivan Franko National University of Lviv, Ukraine;
e-mail: sybirna_natalia@yahoo.com
The effects of agmatine on oxidative and non-oxidative metabolic pathways of L-arginine were investigated both in plasma and erythrocytes under experimental diabetes mellitus. It was indicated, that agmatine prevents the development of oxidative-nitrosative stress in diabetic rats. After treatment of animals by agmatine NO-synthase methabolic pathway of L-arginine is depressed whereas arginase one increases in erythrocytes of rats with experimental diabetes mellitus.
Distribution of 5-fluorouracil between lymphocytes and blood plasma
M. A. Stashkevych, E. V. Khomutov, O. P. Shatova, Yu. V. Dumanskiy, I. I. Zinkovych
M. Gorky Donetsk National Medical University, Ukraine;
e-mail: matviyenko.maryna@gmail.com
In blood plasma of 8 healthy volunteers with resuspended lymphocytes incubated with 5-fluorouracil (5-FU) the drug distribution between cells and liquid was assessed by means of HPLC. Rapid accumulation of 5-FU in lymphocytes was proved (the drug concentration on the 3-rd minute is 2.5-fold higher than in plasma) as well as the absence of temporal changes of 5-FU content both in lymphocytes and blood plasma during 30 minutes of experiment.