Ukr.Biochem.J. 2012; Volume 84, Issue 3, May-Jun, pp. 55-62

The effect of agmatine on L-arginine metabolism in erythrocytes under streptozotocin-induced diabetes in rats

I. V. Ferents, I. V. Brodyak, M. Ya. Lyuta,
V. A. Burda, A. M. Fedorovych, N. O. Sybirna

Ivan Franko National University of Lviv, Ukraine;

The effects of agmatine on oxidative and non-oxidative metabolic pathways of L-arginine were investigated both in plasma and erythrocytes under experimental diabetes mellitus. It was indicated, that agmatine prevents the development of oxidative-nitrosative stress in diabetic rats. After treatment of animals by agmatine NO-synthase methabolic pathway of L-arginine is depressed whereas arginase one increases in erythrocytes of rats with experimental diabetes mellitus.

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