I. V. Ferents, I. V. Brodyak, M. Ya. Lyuta,
V. A. Burda, A. M. Fedorovych, N. O. Sybirna

Ivan Franko National University of Lviv, Ukraine;
e-mail: sybirna_natalia@yahoo.com

The effects of agmatine on oxidative and non-oxidative metabolic pathways of L-arginine were investigated both in plasma and erythrocytes under experimental diabetes mellitus. It was indicated, that agmatine prevents the development of oxidative-nitrosative stress in diabetic rats. After treatment of animals by agmatine NO-synthase methabolic pathway of L-arginine is depressed whereas arginase one increases in erythrocytes of rats with experimental diabetes mellitus.

Keywords: agmatine, arginase, erythrocyte, experimental diabetes mellitus, nitrate, nitrite, NO-synthase, ornitine, plasma