Tag Archives: apelin
Serum apelin and corin as biochemical markers of polycystic ovary syndrome
, , ,
1Al-Turath University, College of Pharmacy, Baghdad, Iraq;
2Department of Biotechnology, College of Science,
University of Baghdad, Baghdad, Iraq;
3Department of Clinical Laboratory Sciences, College of Pharmacy,
Al-Nahrain University, Baghdad, Iraq;
4Department of Chemistry and Biochemistry, College of Medicine,
Al-Nahrain University, Baghdad, Iraq
*e-mail: Nesreen.ahmed@nahrainuniv.edu.iq
Received: 13 January 2026; Revised: 05 March 2026;
Accepted: 29 May 2026; Available on-line: 18 June 2026
Background. Polycystic ovary syndrome (PCOS) is an endocrine-metabolic disease with reproductive dysfunction, intricate hormonal imbalance, elevated risk of cardiovascular disease and obesity in women of reproductive age. Apelin, an adipokine, and corin, a serine protease which activates natriuretic peptide as a cardiovascular regulator, could be involved in the connection between reproductive endocrine imbalance and cardiometabolic regulation in this condition. Objective. To determine apelin and corin levels in the blood of women with PCOS and to evaluate whether they can be useful biochemical predictors for characterizing the disease and stratifying risks. Methods. The case-control study was conducted on 60 women, comprising 30 patients with PCOS and 30 healthy age- and demographically-matched controls. The levels of serum apelin and corin were evaluated with ELISA, that of hormones, 25-hydroxyvitamin D and B12 were analyzed with the help of a Finecare analyser. Results. Much higher apelin and corin levels, increased luteinizing hormone (LH) level and LH/follicle-stimulating hormone ratio, and lower 25-hydroxyvitamin D level in the serum of PCOS patients compared to healthy group were detected. Conclusions. The analysis of ROC curves showed significantly positive relationship between hormonal disturbance and the levels of circulating apelin and corin, indicating their higher PCOS diagnostic accuracy compared to the traditional hormonal markers.
Vitamin D(3) regulates hepatic VEGF-A and apelin expression in experimental type 1 diabetes
D. O. Labudzynskyi1*, I. O. Shymanskyi1, O. O. Lisakovska1,
A. O. Mazanova1, L. V. Natrus2, M. M. Veliky1
1Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv;
2Bogomolets National Medical University, Kyiv, Ukraine;
*e-mail: konsument3@gmail.com
Received: 09 July 2019; Accepted: 15 May 2020
The deficiency of vitamin D is associated with the risk of various chronic diseases, including diabetes mellitus and its complications. Given the strong genomic action of vitamin D hormone-active form, its deficiency can lead to dysfunction of cytokine signaling pathways, including those dependent on vascular endothelial growth factors (VEGFs) and apelin. The present study was carried out to define the link between VEGF-A and apelin expression in liver, hepatocytes viability and vitamin D status at experimental type 1 diabetes in mice. We established that chronic hyperglycemia at streptozotocin-induced diabetes was accompanied by a 2.2-fold decrease in 25OHD content in the serum and increased hepatocytes apoptosis and necrosis. Vitamin D deficiency correlated with increased apelin and VEGF-A (8- and 1.6-fold respectively) expression. Almost complete restoration of circulatory 25OHD content in serum was achieved at vitamin D3 treatment (800 IU/kg, per os, for 2 months) followed by reduced apelin and VEGF-A expression in liver and the decline of hepatocytes apoptosis. We conclude that vitamin D3 can be involved in cell survival, angiogenesis and fibrogenesis by modulating VEGF-A and apelin dependent regulatory systems in diabetic liver.