O. I. Yusova¹, O. V. Savchuk¹, T. V. Grinenko¹, O. B. Kuchmenko², L. S. Mhitaryan², O. H. Kupchins’ka², I. N. Yevstratova², O. O. Matova², N. M. Vasilinchuk², T. F. Drobot’ko²

 ¹Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv;
e-mail: yusova07@gmail.com;
²SI NSC “Strazhesko Institute of Cardiology”, National Academy of Medical Sciences of Ukraine, Kyiv

The present study was investigated of levels of oxidative modification of lipoproteins and content of plasminogen/plasmin system components – tissue-type plasminogen activator (t-PA) and plasminogen activators inhibitor-1 (PAI-1), in patients with stage II arterial hypertension (AHT) and resistant form of AHT. It was established that t-PA level in blood plasma of the patients is 2 times lower under stage II hypertension than normal and 2.5 times lower under resistant AHT. The inhibitor activity is 1.5 and 2 times higher consequently. It is concluded that patients with AHT have a decreased fibrinolytic potential, which can cause thrombotic states. Our evaluation showed a significant accumulation of products of lipid and protein oxidation, decrease of activity of antioxidant enzymes and changes of the activity of high density-lipoproteins-associated enzymes (decrease of paraoxonase-1 activity, increase of myeloperoxidase activity). Oxidized lipoproteins, t-PA and PAI-1 can be used as prognostic markers of development of complications and for evaluating the efficacy of therapy in patients with arterial hypertension.