Ukr.Biochem.J. 2018; Volume 90, Issue 1, Jan-Feb, pp. 58-67


Determination of plasminogen/plasmin system components and indicators of lipoproteins oxidative modification under arterial hypertension

O. I. Yusova1, O. V. Savchuk1, T. V. Grinenko1, O. B. Kuchmenko2, L. S. Mhitaryan2, O. H. Kupchins’ka2, I. N. Yevstratova2, O. O. Matova2, N. M. Vasilinchuk2, T. F. Drobot’ko2

 1Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv;
2SI NSC “Strazhesko Institute of Cardiology”, National Academy of Medical Sciences of Ukraine, Kyiv

The present study was investigated of levels of oxidative modification of lipoproteins and content of plasminogen/plasmin system components – tissue-type plasminogen activator (t-PA) and plasminogen activators inhibitor-1 (PAI-1), in patients with stage II arterial hypertension (AHT) and resistant form of AHT. It was established that t-PA level in blood plasma of the patients is 2 times lower under stage II hypertension than normal and 2.5 times lower under resistant AHT. The inhibitor activity is 1.5 and 2 times higher consequently. It is concluded that patients with AHT have a decreased fibrinolytic potential, which can cause thrombotic states. Our evaluation showed a significant accumulation of products of lipid and protein oxidation, decrease of activity of antioxidant enzymes and changes of the activity of high density-lipoproteins-associated enzymes (decrease of paraoxonase-1 activity, increase of myeloperoxidase activity). Oxidized lipoproteins, t-PA and PAI-1 can be used as prognostic markers of development of complications and for evaluating the efficacy of therapy in patients with arterial hypertension.

Keywords: , , ,


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