Tag Archives: biochemical mechanisms
Biochemical and cellular mechanisms of immunogenic cell death
M. Klishch, N. Skorokhyd, R. Panchuk, R. Stoika*
Institute of Cell Biology, National Academy of Sciences of Ukraine, Lviv, Ukraine;
*e-mail: stoika@cellbiol.lviv.ua; stoika.rostyslav@gmail.com
Received: 26 April 2024; Revised: 11 September 2024;
Accepted: 21 November 2024; Available on-line: 17 December 2024
Immunogenic cell death (ICD) is a mode of programmed cell death that leads to the activation of anticancer immune response and determines the long-term success of anticancer therapies. Here, we provide a review of the known molecular and cellular mechanisms of ICD. Usually, solid tumor experimental models have been used in ICD studies. However, ascites tumor models may possess some advantages over them. The results of our investigation on the approbation of murine Nemeth-Kellner lymphoma as an experimental ascites tumor model for ICD studies are presented.
Biochemical effects of estrogens in non-reproductive organs
A. S. Mikosha, E. I. Kovzun, N. D. Tronko
State Institution V. P. Komisarenko Institute of Endocrinology and Metabolism,
National Academy of Medical Sciences of Ukraine, Kyiv;
e-mail: asmikosha@gmail.com
Biochemical processes initiated by estrogenic hormones in the organs which are not directly related to reproduction were described in the survey on the basis of literature and the authors’ own studies. The importance of these compounds in the regulation of fundamental biological processes has been established in the last decades. The biochemical mechanisms of realization of estrogen effects may be considered as potential links of pathogenesis for a number of diseases and as targets of their therapy.