Tag Archives: fetuin A
Fetuin-A level in patients with untreated thyroid dysfunction
A. S. Idan1*, M. I. Hamzah1, M. S. Khudhair2
1Clinical Biochemistry Department, Al-Nahrain University, Medicine College, Iraq;
2Internal Medicine Department, Al-Nahrain University, Medicine College, Iraq;
*e-mail: alaas3223@gmail.com
Received: 26 August 2023; Revised: 08 November 2023;
Accepted: 01 February 2024; Available on-line: 26 February 2024
Fetuin-A, a plasma glycoprotein, has been demonstrated to play an essential role in the pathogenesis of several metabolic disorders. This study aimed to estimate fetuin-A serum level in patients with newly diagnosed primary hyperthyroidism (PHT) and subclinical hypothyroidism (SCH) and to examine its correlation with thyroid hormones level, age and sex of patients. The study involved 90 patients with untreated thyroid dysfunction verified with thyroid function test (45 with PHT and 45 with SCH) and 90 control subjects. Triiodothyronin (T3), tetraiodothyronin (T4), and thyroid stimulating hormone (TSH) serum concentrations were measured with enzyme-linked fluorescent assay (ELFA), fetuin-A concentration was measured with enzyme-linked immunosorbent assay (ELISA). It was demonstrated that the level of fetuin-A was significantly higher in the PHT group as compared with the control group and showed a significant positive correlation with the T3 level. In the SCH group, the level of fetuin-A was significantly lower and showed a negative correlation with TSH level. Fetuin-A level rose with age in the PHT group and was unaffected by sex in all studied groups. The perfect AUC value obtained for fetuin-A in the comparison between PHT and SCH groups suggests its potential use as a reliable diagnostic marker to differentiate between these two thyroid conditions.
Biological role of fetuin A and its potential importance for prediction of cardiovascular risk in patients with type 2 diabetes mellitus
M. Yu. Gorshunska1, Y. I. Karachentsev1,2, N. A. Kravchun2, E. Jansen3,
Zh. A. Leshchenko2, A. I. Gladkih2, N. S. Krasova2,
T. V. Tyzhnenko2, Y. A. Opaleyko2, V. V. Роltorak2
1Kharkiv Postgraduate Medical Academy,Ukraine;
2SI V. Danilevsky Institute of Endocrine Pathology Problems,
National Academy of Medical Sciences of Ukraine, Kharkiv;
3National Institute for Public Health and the Environment,
Bilthoven, Netherlands;
e-mail: maryanagr@mail.ru
The authors’ data and those from literature concerning biological role of fetuin A glycoprotein have been generalized in the article. A direct correlation has been established between fetuin A and some adipokines involved in the formation of insulin resistance and atherogenesis (progranulin, omentin-1), and osteoprotegerin (the novel cardiovascular risk factor) as well as an increase of circulating levels of fetuin A in patients with type 2 diabetes mellitus with high cardiovascular risk metabolic pattern but without manifestations of macrovascular complications. This substantiates the involvement of fetuin A in the complex of biomarkers of subclinical atherosclerosis.