I. Kostovska

Faculty of Medicine, Ss Cyril and Methodius University in Skopje, North Macedonia;
e-mail: irenakostovska22@yahoo.com

Received: 16 December 2024; Revised: 10 February 2025;
Accepted: 25 April 2025 2025; Available on-line: 12 May 2025

Selectivity of blood filtration by the renal glomerulus is largely determined by the presence in its visceral epithelium of the terminally differentiated “octopus-like” cells called podocytes. Podocalyxin (PODXL) is a major transmembrane glycoprotein located on the podocytes’ apical surface. Recently, the appearance of PODXL in urine has been considered a marker of nephropathy. The purpose of this review article is to analyze the data of studies on the structural and functional features of podocalyxin and its value in diagnostic, prognostic and potential therapeutic relevance in most common kidney diseases.