S. V. Khyzhnyak*, S. V. Midyk, A. O. Velinska,
О. V. Arnauta, L. Н. Kalachniuk

National University of Life and Environmental Sciences of Ukraine, Kyiv;
*e-mail: khyzhnyaks@gmail.com

Received: 18 August 2022; Revised: 24 October 2022;
Accepted: 04 November 2022; Available on-line: 14 November 2022

The widespread use of fungicides in agriculture leads to a negative consequences for both humans and the environment. The acute effect of fungicides containing tebuconazole alone or in combination with triadimefon on fatty acid (FAs) composition of the total lipids in the liver of rats was studied. FAs content was analyzed by gas chromatography with the use of flame ionization detector. The results obtained indicate that the acute effect of triazole fungicides one-time oral administration to rats is characterized by toxic reactions and is accompanied by the total liver lipids FAs profile redistribution, similar for the studied fungicides. In particular, the reduction in the total content of monounsaturated FAs (by 26% – 37%) and in the ω3/ω6 ratio was observed. It was demonstrated that the subsequent two-week introduction of the preparation based on Milk thistle seeds oil extract had a positive effect and improved the FAs profile of lipids in dynamics after fungicide intake.