Tag Archives: paraoxonase-1

The oxidative status in patients with chronic kidney disease

V. S. Vasylchenko1,2*, L. V. Korol1, O. B. Kuchmenko2, N. M. Stepanova1

1State Institution “Institute of Nephrology of the National Academy
of Medical Sciences of Ukraine”, Kyiv;
2National University of Kyiv-Mohyla Academy, Ukraine;
*e-mail: vasylchenkovita@gmail.com

Received: 26 March 2020; Accepted: 25 June 2020

An excess of free radicals accompanies the development of renal pathologies and causes numerous concomitant complications and syndromes. The most common of these are cardiometabolic syndromes in patients with chronic kidney disease. Therefore, the purpose of the study was to determine the activity of paraoxonase-1 and myeloperoxidase, which are associated with indicators of high-density lipoproteins content and oxidative stress in the blood of patients with the chronic stage of kidney disease. The activity of the enzymes, thiobarbiturate-active products concentration and  transferrin, ceruloplasmin, thiol compounds content were determined in the blood of patients with chronic kidney disease. The oxidative status was shown to be changed. Thus, myeloperoxidase activity, the content of  oxidized proteins and the concentration of thiobarbiturate-positive components were increased, while  the activity of the antioxidant enzyme paraoxonase-1, the content of transferrin, ceruloplasmin and thiol compounds were decreased. The ratio of myeloperoxidase/paraoxonase-1 activities was progressively increased up to 9-fold, indicating the presence of cardiovascular complications in patients. The data obtained allowed to extend the range of indicators for monitoring the development of cardiometabolic disorders in the progression of chronic kidney disease.