L. B. Oriabinska¹, S. О. Starovoitova², S. V. Vasylyuk³,
V. P. Novikov³, V. І. Lubenets³

¹National Technical University of Ukraine “Igor Sikorsky Kyiv Polytechnic Institute”;
²National University of Food Technologies, Kyiv, Ukraine;
³Lviv Polytechnic National University, Ukraine;
е-mail: vlubenets@gmail.com

The problem of resistance of microorganisms to antibiotics stimulates the search for new chemotherapy drugs. Ethylthiosulfanilate (ETS, S-ethyl 4-amino-benzenesulfonothioate, S-ethyl ester of 4-aminobenzenethiosulfoacid) as a structural analog of number of phytoncides was synthesized based on thiosulfoacid salts. ETS effect on opportunistic yeast fungi Candida tropicalis was studied. It was shown that ETS in subfungicidal concentration (125 µg/ml) affected some aspects of a constructive and energy metabolism of fungi: inhibited endogenous respiration and reduced the pool of nucleic acids. Additionaly the significant changes in lipogenesis of C. tropicalis were detected. It was established that ETS in fungistatic and subfungicidal concentrations possessed membranotropic effect and provided a high degree of cooperativity of structural transitions of membranes.