H. N. Shiyntum¹, O. O. Dovban¹, Y. P. Kovalchuk¹,
T. Ya. Yaroshenko², G. A. Ushakova¹

¹Oles Honchar Dnipro National University, Ukraine;
²I. Horbachevsky Ternopil State Medical University, Ukraine;
e-mail: hnkafor@yahoo.com

In this research, we investigated the effect of pituitrin-izadrin induced injury on the levels of metallothionein (MT) and soluble and filament forms of glial fibrillary acidic protein (GFAP) in the hippocampus, cerebellum, thalamus, and the cerebral cortex, and examined the effect of corvitin on the brain under the noted changes. Our results showed oppositely directed changes – a decrease in the level of MT and an increase in GFAP in the rat brain, with a tendency to astrogliosis development, under the influence of systemic deficiencies in myocardial function. The use of corvitin at a dose of 42 mg/kg for five days after a cardiac attack caused by pituitary-izadrin leads to recovery in the balance of the studied proteins.