Tag Archives: vitamin B12
“Oxford housewife” or the only british woman to have ever won the Nobel Prize in science? – Dorothy Hodgkin
V. M. Danilova*, S. G. Torkhova, S. V. Komisarenko
Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv;
*e-mail: valdan@biochem.kiev.ua
Received: 05 November 2024; Revised: 18 November 2024;
Accepted: 21 November 2024; Available on-line: 15 January 2025
Dorothy Crowfoot Hodgkin, a British chemist and Nobel Prize winner, who extended the method of X-ray crystallography to determine the structure of biomolecules that furthered the development of structural biology. In 1964, she was awarded the Nobel Prize in Chemistry “for the determinations by X-ray techniques of the structures of important biochemical substances”, particularly vitamin B12 and antibiotic penicillin. Five years after winning the Nobel Prize, Dorothy Hodgkin also established the structure of insulin. Although The Daily Mail headlined her as an “Oxford housewife”, Dorothy Hodgkin overcame gender inequality to become the third woman in history to win the Nobel Prize in Chemistry and remains the only British woman researcher to be awarded the most prestigious prize in the sciences.
Pyridoxine, folate, and cobalamin and the condition of the innate and acquired immunity
M. I. Kinash, O. R. Boyarchuk
Ivan Horbachevsky Ternopil National Medical University, Ukraine;
e-mail: kinash@tdmu.edu.ua, boyarchuk@tdmu.edu.ua
Received: 23 September 2021; Accepted: 21 January 2022
The immune response to the pathogen depends on the state and coordinated activity of innate and acquired immunity. To date, the positive role of many micronutrients (vitamins and minerals) in maintaining homeostasis of the human immune system has been proven. The aim of the review was to analyze the main manifestations of vitamins B6, B9, B12 influence on the state of innate and adaptive immunity. These vitamins play an important role in the synthesis of DNA and RNA, cytokines and immunoglobulins, thus maintaining the proper state of the immune system. The functioning of the main links of specific and nonspecific immunity at the normal vitamin status and at pyridoxine, folate and cobalamin deficiency is compared.