Tag Archives: yeast

Yeast concentration in the diet defines Drosophila metabolism of both parental and offspring generations

O. M. Strilbytska1*, N. P. Stefanyshyn1,
U. V. Semaniuk1, O. V. Lushchak1,2*

1Department of Biochemistry and Biotechnology, Vasyl Stefanyk Precarpathian National University, Ivano-Frankivsk, Ukraine;
2Research and Development University, Ivano-Frankivsk, Ukraine;
*e-mail: olya_b08@ukr.net or oleh.lushchak@pnu.edu.ua

Received: 18 April 2021; Accepted: 12 November 2021

Parental dietary nutrients epigenetically influence offspring metabolism. Our analysis revealed unforeseen patterns in how enzymes of the main metabolic pathways respond to protein content in the diet. We reared parental flies Drosophila melanogaster on four types of diet with different dry yeast concentrations ranging from 0.25% to 15%. The subsequent generation was fed by the same diet, so the only variable in the experiments was the yeast concentration in the parental diet. We showed that protein restriction in the parental diet led to higher lactate dehydrogenase (LDH) activity in parents, and this effect was inherited in their progeny. The transgenerational effect of parental dietary yeast on malate dehydrogenase (MDH) activity was found only in males. An elevated level of dietary yeast was sufficient to enhance alanine transaminase ( ALT) and aspartate transaminase (AST) activity in parents, however, did not affect ALT activity and decreased AST  in their offspring. A low yeast parental diet was shown to cause higher urea content in F1 males. It is concluded that parental dietary yeast plays a critical role in metabolic health that can be inherited through generation.

Laureates of the Palladin Prize of the National Academy of Sciences of Ukraine (2005, 2007 years)

R. P. Vynogradova ,  V. M. Danilova 

Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv;
e-mail: valdan@biochem.kiev.ua

The article presents biographical information and analysis of scientific activity of laureates of the Palladin Prize of NAS of Ukraine. In 2005 L. I. Ostapchenko and A.A. Sibirny were awarded for the series of works “Molecular mechanisms of metabolism regulation and their application  in biology and biotechnology” and in 2007 O. G. Minchenko received the prize for the series of works “Molecular mechanisms of regulation of gene expression” published between 2001 and 2005.