Ukr.Biochem.J. 2011; Volume 83, Issue 6, Nov-Dec, pp. 5-34

Role of PARP and protein poly-ADP-ribosylation process in regulation of cell functions

V. R. Drel1, I. O. Shymanskyy2, N. О. Sybirna1, M. M. Veliky2

1Ivan Franko National University of Lviv, Ukraine;
2Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv;

This review focuses on the biological role of enzymes involved in posttranslational modification of proteins by their poly-ADP-ribosylation, a NAD-consuming process with an emerging key role in providing fundamental cell functions. To this end, detailed analysis of structural organization in relation to basic functions of the poly(ADP-ribose)polymerase-1 (PARP-1), the founding member of the PARP family, and other poly(ADP-ribose)polymerase isoforms is presented here. These include the current views on the role of PARP family enzymes and processes of poly-ADP-ribosylation of proteins in chromatin structure remodeling, DNA damage repair, regulation of gene expression, and integration of cellular signaling pathways. Considerable attention is paid to the involvement of PARP in cellular functions, particularly in cell division, intracellular transport of macromolcules, proteasomal protein degradation, immune response and caspase-independent necrotic pathways defined as necroptosis (programmed necrosis). In the light of the remarkable successes that have been reported for treating inflammatory disorders and cancer with different classes of PARPs inhibitors, we discuss the prospects of targeting PARPs with therapeutic purposes.

Keywords: , , , , , ,

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License.