Ukr.Biochem.J. 2021; Volume 93, Issue 1, Jan-Feb, pp. 5-17


Coronavirus viroporins: structure and function

I. Zaloilo1, Y. Rud2, О. Zaloilo2, L. Buchatskyi2

1National University of Life and Environmental Sciences of Ukraine, Kyiv;
2ESC Institute of Biology and Medicine, Taras Shevchenko National University of Kyiv, Ukraine;

Received: 08 July 2020; Accepted: 17 December 2020

Viroporins are involved in viral pathogenesis, play an important role in the morphogenesis of virions and ensure their release from the infected cell. These proteins are potentially promising as possible targets for the regulation of virus reproduction. The literature data on the current understanding of coronavirus viroporins functioning are summarized in the review. Special attention is focused on specific structural features that determine the functional ability of these proteins. The basic principles of viroporins localization in the cell and their influence on the coronavirus life cycle are considered.

Keywords: , , , , , ,


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