Ukr.Biochem.J. 2023; Volume 95, Issue 1, Jan-Feb, pp. 103-116
doi: https://doi.org/10.15407/ubj95.01.0103
Genome secrets of extinct hominids, or can paleogenomics answer the question: humankind, who we are? Nobel Prize in Physiology or Medicine 2022
S. V. Komisarenko, S. I. Romaniuk
Paladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv;
e-mail: svk@biochem.kiev.ua
Received: 28 February 2022; Revised: 02 March 2022;
Accepted: 13 April 2023; Available on-line: 27 April 2023
The Nobel Prize in Physiology or Medicine 2022 was awarded to Professor Svante Pääbo, a Swedish paleogenetic researcher, specialist in the field of evolutionary genetics, Director of the Department of Evolutionary Genetics at the Max Planck Institute for Evolutionary Anthropology of Leipzig (Germany), for “discoveries concerning the genomes of extinct hominids and human evolution”. Explaining the significance of S. Pääbo’s work, the Nobel Committee noted that “he pioneered the methods to isolate and analyze DNA from archaic bone remains. In ancient bones, DNA has decayed, been chemically damaged and massively contaminated with DNA from bacteria and contemporary humans who work with the samples. Having utilized modern genetic methods, S. Pääbo created his own methods of sequencing the ancient DNA”.
Keywords: genome, hominids, human evolution, Nobel Prize in Physiology or Medicine 2022, Svante Pääbo
References:
- Physiology or Medicine. 2022 Citation Laureates. Regime of access : https://clarivate.com/citation-laureates/physiology-or-medicine-2022/
- Press release: The Nobel Prize in Physiology or Medicine 2022. Regime of access : https://www.nobelprize.org/prizes/medicine/2022/press-release/
- Svante Pääbo. Wikipedia. Regime of access : https://en.wikipedia.org/wiki/Svante_Pääbo
- Hedestam G.K. Discoveries concerning the genomes of extinct hominins and human evolution. Regime of access : https://www.nobelprize.org/prizes/medicine/2022/advanced-information/
- Zuckerkandl E, Pauling L. Molecules as documents of evolutionary history. J Theor Biol. 1965;8(2):357-366. PubMed, CrossRef
- Pääbo S. Molecular cloning of Ancient Egyptian mummy DNA. Nature. 1985;314(6012):644-645. PubMed, CrossRef
- Cann RL, Stoneking M, Wilson AC. Mitochondrial DNA and human evolution. Nature. 1987;325(6099):31-36. PubMed, CrossRef
- Pääbo S, Wilson AC. Polymerase chain reaction reveals cloning artefacts. Nature. 1988;334(6181):387-388. PubMed, CrossRef
- Kocher TD, Thomas WK, Meyer A, Edwards SV, Pääbo S, Villablanca FX, Wilson AC. Dynamics of mitochondrial DNA evolution in animals: amplification and sequencing with conserved primers. Proc Natl Acad Sci USA. 1989;86(16):6196-6200. PubMed, PubMedCentral, CrossRef
- Poinar HN, Höss M, Bada JL, Pääbo S. Amino acid racemization and the preservation of ancient DNA. Science. 1996;272(5263):864-866. PubMed, CrossRef
- Mooallemjan J. Neanderthals were people, too. Regime of access : https://www.nytimes.com/2017/01/11/magazine/neanderthals-were-people-too.html.
- Krings M, Stone A, Schmitz RW, Krainitzki H, Stoneking M, Pääbo S. Neandertal DNA sequences and the origin of modern humans. Cell. 1997;90(1):19-30. PubMed, CrossRef
- Lander ES, Linton LM, Birren B, 253 co-authors; International Human Genome Sequencing Consortium. Initial sequencing and analysis of the human genome. Nature. 2001.409(6822):860-921. PubMed, CrossRef
- Nurk S, Koren S, Rhie A, 96 co-authors, Phillippy AM. The complete sequence of a human genome. Science. 2022r;376(6588):44-53. PubMed, PubMedCentral, CrossRef
- Venter JC, Adams MD, Myers EW, 270 co-authors, Zhu X. The sequence of the human genome. Science. 2001;291(5507):1304-1351.
PubMed, CrossRef - Margulies M, Egholm M, Altman WE, 52 co-authors, Rothberg JM. Genome sequencing in microfabricated high-density picolitre reactors. Nature. 2005;437(7057):376-380. PubMed, PubMedCentral, CrossRef
- Green RE, Krause J, Briggs AW, 52 co-authors, Pääbo S. A draft sequence of the Neandertal genome. Science. 2010;328(5979):710-722. PubMed, PubMedCentral, CrossRef
- Krause J, Fu Q, Good JM, Viola B, Shunkov MV, Derevianko AP, Pääbo S. The complete mitochondrial DNA genome of an unknown hominin from southern Siberia. Nature. 2010;464(7290):894-897. PubMed, CrossRef
- Meyer M, Kircher M, Gansauge MT, 30 co-authors, Pääbo S. A high-coverage genome sequence from an archaic Denisovan individual. Science. 2012;338(6104):222-226. PubMed, PubMedCentral, CrossRef
- Fu Q, Hajdinjak M, Moldovan OT, 12 coauthors, Pääbo S. An early modern human from Romania with a recent Neanderthal ancestor. Nature. 2015;524(7564):216-219. PubMed, PubMedCentral, CrossRef
- Fu Q, Li H, Moorjani P, 24 coauthors, Pääbo S. Genome sequence of a 45,000-year-old modern human from western Siberia. Nature. 2014;514(7523):445-449. PubMed, PubMedCentral, CrossRef
- Callaway E. Modern human genomes reveal our inner Neanderthal. Regime of access : https://www.nature.com/articles/nature.2014.14615.
- Gibbons A. Modern human females and male Neandertals had trouble making babies. Here’s why. Regime of access : https://www.science.org/content/article/modern-human-females-and-male-neandertals-had-trouble-making-babies-here-s-why
- Uthmeier T. On the trail of the last Neanderthals. Regime of access : https://www.fau.eu/2013/06/05/news/research/on-the-trail-of-the-last-neanderthals/
- Prüfer K, Racimo F, Patterson N, 41 co-authors, Pääbo S. The complete genome sequence of a Neanderthal from the Altai Mountains. Nature. 2014;505(7481):43-49. PubMed, PubMedCentral, CrossRef
- Krause J, Lalueza-Fox C, Orlando L, Enard W, Green RE, Burbano HA, Hublin JJ, Hänni C, Fortea J, de la Rasilla M, Bertranpetit J, Rosas A, Pääbo S. The derived FOXP2 variant of modern humans was shared with Neandertals. Curr Biol. 2007;17(21):1908-1912. PubMed, CrossRef
- Huerta-Sánchez E, Jin X, Asan, 23 coauthors, Nielsen R. Altitude adaptation in Tibetans caused by introgression of Denisovan-like DNA. Nature. 2014;512(7513):194-197. PubMed, PubMedCentral, CrossRef
- Dannemann M, Kelso J. The Contribution of Neanderthals to Phenotypic Variation in Modern Humans. Am J Hum Genet. 2017;101(4):578-589. PubMed, PubMedCentral, CrossRef
- Ding Q, Hu Y, Xu S, Wang J, Jin L. Neanderthal introgression at chromosome 3p21.31 was under positive natural selection in East Asians. Mol Biol Evol. 2014;31(3):683-695. PubMed, CrossRef
- Dannemann M, Andrés AM, Kelso J. Introgression of Neandertal- and Denisovan-like Haplotypes Contributes to Adaptive Variation in Human Toll-like Receptors. Am J Hum Genet. 2016;98(1):22-33. PubMed, PubMedCentral, CrossRef
- Mendez FL, Watkins JC, Hammer MF. A haplotype at STAT2 Introgressed from neanderthals and serves as a candidate of positive selection in Papua New Guinea. Am J Hum Genet. 2012;91(2):265-274. PubMed, PubMedCentral, CrossRef
- Mendez FL, Watkins JC, Hammer MF. Neandertal origin of genetic variation at the cluster of OAS immunity genes. Mol Biol Evol. 2013;30(4):798-801. PubMed, CrossRef
- Zeberg H, Pääbo S. A genomic region associated with protection against severe COVID-19 is inherited from Neandertals. Proc Natl Acad Sci USA. 2021;118(9):e2026309118. PubMed, PubMedCentral, CrossRef
- Zeberg H, Pääbo S. The major genetic risk factor for severe COVID-19 is inherited from Neanderthals. Nature. 2020;587(7835):610-612. PubMed, CrossRef
- Zimmer C. Man’s genome from 45,000 years ago is reconstructed. Regime of access : https://www.nytimes.com/2014/10/23/science/research-humans-interbred-with-neanderthals.html
- Meyer M, Arsuaga JL, de Filippo C, Nagel S, Aximu-Petri A, Nickel B, Martínez I, Gracia A, Bermúdez de Castro JM, Carbonell E, Viola B, Kelso J, Prüfer K, Pääbo S. Nuclear DNA sequences from the Middle Pleistocene Sima de los Huesos hominins. Nature. 2016;531(7595):504-507. PubMed, CrossRef
- 1000 Genomes Project Consortium, Abecasis GR, Altshuler D, Auton A, Brooks LD, Durbin RM, Gibbs RA, Hurles ME, McVean GA. A map of human genome variation from population-scale sequencing. Nature. 2010;467(7319):1061-1073. PubMed, PubMedCentral, CrossRef
- Mallick S, Li H, Lipson M, 75 co-authors, Reich D. The Simons Genome Diversity Project: 300 genomes from 142 diverse populations. Nature. 2016;538(7624):201-206. PubMed, PubMedCentral, CrossRef
- Moraes F, Góes A. A decade of human genome project conclusion: Scientific diffusion about our genome knowledge. Biochem Mol Biol Educ. 2016;44(3):215-223. PubMed, CrossRef
- Davis N. Ancient Siberia was home to previously unknown humans, say scientists. Regime of access : https://www.theguardian.com/science/2019/jun/05/ancient-siberia-was-home-to-previously-unknown-humans-say-scientists
- Wade L. Mummy genomes reveal just how catastrophic European contact was for New World. Regime of access : https://www.science.org/content/article/mummy-genomes-reveal-just-how-catastrophic-european-contact-was-new-world.
- Price M. Oldest cousin of Native Americans found in Russia. Regime of access : https://www.science.org/content/article/oldest-cousin-native-americans-found-russia.
- Balter M. Mysterious Indo-European homeland may have been in the steppes of Ukraine and Russia. Regime of access : https://www.science.org/content/article/mysterious-indo-european-homeland-may-have-been-steppes-ukraine-and-russia
- Yamnaya culture. Wikipedia. Regime of access : https://en.wikipedia.org/wiki/Yamnaya_culture
- Pennisi E. Humans are still evolving – and we can watch it happen. Regime of access : https://www.science.org/content/article/humans-are-still-evolving-and-we-can-watch-it-happen
- Gibbons A. How Europeans evolved white skin. Regime of access : https://www.science.org/content/article/how-europeans-evolved-white-skin
- Gramling C. The ‘hobbit’ was a separate species of human, new dating reveals. Regime of access : https://www.science.org/content/article/hobbit-was-separate-species-human-new-dating-reveals
- Gibbons A. New human species discovered. Regime of access : https://www.science.org/doi/10.1126/science.349.6253.1149
- Gibbons A. First DNA extracted from an ancient African skeleton shows widespread mixing with Eurasians. Regime of access : https://www.science.org/content/article/first-dna-extracted-ancient-african-skeleton-shows-widespread-mixing-eurasians
- Price M. Africans, too, carry Neanderthal genetic legacy. Science. 2020;367(6477):497. PubMed, CrossRef
- Marchant J. Egyptian mummies yield genetic secrets. Regime of access : https://www.nature.com/news/egyptian-mummies-yield-genetic-secrets-1.12793
- Gibbons A. DNA from cave dirt tells tale of how some Neanderthals disappeared. Regime of access : https://www.science.org/content/article/dna-cave-dirt-tells-tale-how-some-neanderthals-disappeared
- Warren M. Biggest Denisovan fossil yet spills ancient human’s secrets. Nature. 2019;569(7754):16-17. PubMed, CrossRef
- Bahrampour T. They considered themselves white, but DNA tests told a more complex story. Regime of access : https://www.washingtonpost.com/local/social-issues/they-considered-themselves-white-but-dna-tests-told-a-more-complex-story/2018/02/06/16215d1a-e181-11e7-8679-a9728984779c_story.html
- Vasiljevic N, Lim M, Humble E, Seah A, Kratzer A, Morf NV, Prost S, Ogden R. Developmental validation of Oxford Nanopore Technology MinION sequence data and the NGSpeciesID bioinformatic pipeline for forensic genetic species identification. Forensic Sci Int Genet. 2021;53:102493. PubMed, CrossRef
- Ponce de León MS, Bienvenu T, Marom A, Engel S, Tafforeau P, Alatorre Warren JL, Lordkipanidze D, Kurniawan I, Murti DB, Suriyanto RA, Koesbardiati T, Zollikofer CPE. The primitive brain of early Homo. Science. 2021;372(6538):165-171. PubMed, CrossRef
- Richerson PJ, Gavrilets S, de Waal FBM. Modern theories of human evolution foreshadowed by Darwin’s Descent of Man. Science. 2021;372(6544):eaba3776. PubMed, CrossRef
- Dolgin E. Evolutionary sprint made us human. Regime of access : https://www.science.org/content/article/evolutionary-sprint-made-us-human
- Pennisi E. Virus fighter may have played a key role in human evolution. Regime of access : https://www.science.org/content/article/virus-fighter-may-have-played-key-role-human-evolution
- Reardon S. Step aside CRISPR, RNA editing is taking off. Nature. 2020;578(7793):24-27. PubMed, CrossRef
- Grover N. Swedish geneticist wins Nobel medicine prize for decoding ancient DNA. Regime of access : https://www.reuters.com/world/svante-paabo-wins-2022-nobel-prize-medicine-2022-10-03/
