M. Yu. Gorshunska¹, Y. I. Karachentsev^1,2, N. A. Kravchun2, E. Jansen³,
Zh. A. Leshchenko², A. I. Gladkih², N. S. Krasova²,
T. V. Tyzhnenko², Y. A. Opaleyko2, V. V. Роltorak²

¹Kharkiv Postgraduate Medical Academy,Ukraine;
²SI V. Danilevsky Institute of Endocrine Pathology Problems,
National Academy of Medical Sciences of Ukraine, Kharkiv;
³National Institute for Public Health and the Environment,
Bilthoven, Netherlands;
e-mail: maryanagr@mail.ru

The authors’ data and those from literature concerning biological role of fetuin A glycoprotein have been generalized in the article. A direct correlation has been established between fetuin A and some adipokines involved in the formation of insulin resistance and atherogenesis (progranu­lin, omentin-1), and osteoprotegerin (the novel cardiovascular risk factor) as well as an increase of circulating levels of fetuin A in patients with type 2 diabetes mellitus with high cardiovascular risk metabolic pattern but without manifestations of macrovascular complications. This substantiates the involvement of fetuin A in the complex of biomarkers of subclinical atherosclerosis.