H. L. Hayrapetyan, N. Kh. Khachatryan, R. R. Balagyozyan,
V. R. Balagyozyan, S. S. Mardanyan*, A. A. Antonyan

Department of Metabolism of Adenylic Compounds,
H. Buniatian Institute of Biochemistry of Armenian NAS, Yerevan, Armenia;
*e-mail: biochem@biochem.sci.am

Received: 09 September 2025; Revised: 22 October 2025;
Accepted: 30 January 2026; Available on-line: February 2026

γ-Aminobutyric acid (GABA) is a non-proteinogenic amino acid, neurotransmitter and concurrently trophic factor in the non-neuronal peripheral tissues. GABA is involved in the pathophysiology of endocrine disorders, in particular, diabetes mellitus (DM). This review summarizes the effects of GABA-ergic system components on the development of experimental diabetes induced in laboratory animals. The beneficial effect of GABA-associated amino acids mixtures in the DM treatment is discussed.