Tag Archives: iodine

Research on diet features of patients with hypothyroidism

O. Oliynyk

Pope John Paul II State School of Higher Education in Biała Podlaska, Poland;
e-mail: Alexanderoliynyk8@gmail.com

Received: 17 April 2020; Accepted: 13 November 2020

Studies on the relationship between dietary features and hypothyroidism pathogenesis are highly relevant­. The aim of this research was to study the dietary features of patients with hypothyroidism and to determine the possible impact of patients’ food preferences on the pathogenesis of hypothyroidism. We examined 400 women of Polish nationality aged 19-28 years living in the district of Biała Podlaski of the Lublin Voivodeship of Poland who consider themselves healthy.  Blood levels of free (FT3) and total (T3) triiodothyronine, free (FT4) and total (T4) thyroxine, thyroid-stimulating hormone (TSH) were determined. The quantitative and qualitative composition of the examined women’s diet was determined using questionnaires and nutritional tables. It was revealed, that the prevalence of hypothyroidism among the female subjects was 3.5%. Women with reduced thyroid function were shown to consume 3.78 times less iodine, 2.97 times (P < 0.001) less sodium chloride (table salt), and 1.47 times (P < 0.001) less proteins than those who had normal thyroid function. In addition, women with hypothyroidism consume  2.25 times (P < 0.001) more strumogenic. It is concluded that the use of such the diet could cause a secondary reduction in thyroid function with further development of the hypothyroidism.

Trace elements storage peculiarities and metallothionein content in human thyroid gland under iodine deficiency euthyroid nodular goiter

H. I. Falfushynska1,2, L. L. Gnatyshyna1, O. Osadchuk2, V. O. Shidlovski2, О. B. Stoliar1

1Ternopil Volodymyr Hnatiuk National Pedagogical University, Ukraine;
2I.Ya. Horbachevski Ternopil State Medical University, Ukraine;
e-mail: halynka.f@gmail.com

Accumulation of iodine and copper in the node, paranodular and contralateral (not affected tissue by node) tissues of thyroid gland in relation to the level of metal-binding proteins, potential antioxidants and oxidative changes in tissue was investigated. To assess the severity of the pathological process the molecular markers of cytotoxicity were used. The reduction of total iodine (by 19.5%), increase of inorganic iodine fraction (by 82.4%) and total copper content (twice) in paranodular and nodular tissues compared with contrlateral part have been established. Excess of copper in goitrous-changes tissue was partially accumulated in the metallothioneins. The level of metal-binding form of metallothioneins and reserve of free thiols of these proteins was higher two-three times and lower content of reduced glutathione in node-affected tissue compared to the contralateral part. Signs of cytotoxicity among them: higher cathepsine D free activity (up to 84.6% and 134.4% in paranodular tissue and node respectively) and higher level of DNA strand breaks in the node (up to 22.6%) were observed. In paranodular tissue the range of indices variability compared with parenchyma of contralateral part is shorter than in the node. Thus, under low level of iodine organification and high copper level in goitrous-modified tissue of thyroid gland metallothionein may provide a partial compensatory effect on prooxidative processes.