Tag Archives: myocardial infarction
The level of inflammatory markers in patients with myocardial infarction after percutaneous coronary intervention
Hadeel S. Abd-Alwahab1, Bayadir Abdul Hussein Mahmeed1,
Nesreen Ahmed Nasser1, Osama A. Mohsein2,3*
1College of Medicine, Al-Nahrain University, Baghdad, Iraq;
2Main Laboratory Unit, Al Habbobi Teaching Hospital,
Thi-Qar Health Directorate, Thi-Qar, Iraq;
3Department of Medical Laboratory Techniques,
Mazaya University College, Thi-Qar, Iraq;
*e-mail: osamaakram889@gmail.com
Received: 04 April 2024; Revised: 20 June 2024;
Accepted: 25 July 2024; Available on-line: 04 September 2024
Cardiovascular diseases are among the most widespread diseases in the world that affect all ages and sometimes can lead to death. Atherosclerosis, coronary syndrome and myocardial infarction are usually associated with artery occlusion and require percutaneous coronary intervention (PCI) as a non-surgical procedure to restore blood flow to the heart. Inflammatory biomarkers, especially interleukins and cardiac biomarkers, have an important role in diagnosing the state of patients with heart damage. The goal of the study was to estimate the serum levels of interleukins and cardiac biomarkers after PCI to reduce the risk of acute coronary syndrome. The study included 100 persons between the ages of 40 and 69 diagnosed with acute coronary syndrome who had successful PCI and a control group consisting of 50 healthy participants of the same age. The levels of interleukins, сreatine kinase MB and myoglobin were measured using an enzyme-linked immunosorbent assay. Troponin and D-dimer levels were measured using immunoassay. It was found that patients before PCI had significantly higher levels of IL-1β, IL-6, IL-8, cardiac troponin I, D-dimer, creatine kinase-MB and myoglobin compared to the control group. One day after PCI, the levels of IL -6, IL-8, cardiac troponin I and D-dimer remained elevated. One week after PCI, the levels of IL-1β, IL-6, IL-8, CK-MB and myoglobin did not show significant differences compared to the control group, while the levels of cardiac troponin I and D-dimer remained higher. Results obtained indicate that in patients after PCI, the levels of interleukins decreased, indicating the reduction of inflammatory processes, but cardiac damage persists to a certain degree, even a week after PCI.
Influence of ademol on NO metabolism indices in rats with modeling myocardial infarction
O. A. Khodakovskiy1, S. V. Pavlov2, N. V. Buchtiyarova2
1Vinnitsa National Pirogov Memorial Medical University, Ukraine;
2Zaporizhzhia State Medical University, Ukraine;
e-mail: aleksey.hodakovskiy@bk.ru
It was established in experiments on the rats in the acute period of modeling pituitrin-isadrin myocardial infarction the formation of nitrogen monoxide decreases along with its accelerated transformation into peroxynitrite. It was evidenced by more than double inhibition of NO synthase activity in the myocardium and by decreasing the amount of nitrates on the background of the increasing level of peroxynitrites’ marker – nitrotyrosine by 246.6% at an average. Experimental therapy of rats by ademol which is a derivate of adamantan (1-adamantiloxy-3-morpholino-2 propanol hydrochloride) better than by corvitin normalizes the processes of synthesis of nitric oxide. At the same time ademol probably exceeded the reference drug in ability to increase NO synthase activity and amount of nitrate, and promoted a decrease of the level of nitrotyrosine in the myocardium on the average by 36.3; 50.6 and 12.7%, respectively. Corrective influence of ademol on indicators of metabolism in NO system under the conditions of acute cardiac ischemia indicates to promicing development of domestic cardioprotector on its base.