Tag Archives: probiotics
Major depressive disorder and the microbiome-gut-brain axis
F. H. Ouriaghli, I. A. Elhaty*
Department of Nutrition and Dietetics, Faculty of Health Sciences,
Istanbul Gelisim University, Istanbul, Türkiye;
*e-mail: iaeismail@gelisim.edu.tr
Received: 02 January 2025; Revised: 24 April 2025;
Accepted: 25 April 2025; Available on-line: 12 May 2025
The central nervous system and the gastrointestinal tract are connected bidirectionally via the gut-brain axis (GBA). According to the gut microbiota hypothesis, changes in the composition and activity of the gut microbiota can affect the GBA, contributing to the onset of mental illnesses such as depression and anxiety. This review aims to analyze how microbiota imbalances can affect the functioning of the gut-brain axis, causing changes in metabolism, immune system and neurotransmitters that are associated with depression. The potential of dietary modifications, probiotics, prebiotics and symbiotics to restore microbiota balance as well as the importance of microbiota profiling integration into personalized clinical practice are discussed.
Influence of oxidative stress on the level of genes expression TGFB1 and HGF in rat liver upon long-term gastric hypochlorhydria and administration of multiprobiotic Symbiter
K. O. Dvorshchenko, O. O. Bernyk, A. S. Dranitsina, S. A. Senin, L. I. Ostapchenko
Taras Shevchenko National University of Kyiv, Ukraine;
e-mail: k21037@gmail.com
Free-radical processes upon long-term omeprazole-induced gastric hypochlorhydria in the rat liver were researched. Intensification of oxidative processes in the liver tissue upon gastric hypoacid state was established: overproduction of superoxide anion, hydrogen peroxide, the quantitative changes of lipid functional groups, increased level of lipid peroxidation products, and augmentation of xanthine oxidase activity. The expression of Tgfb1 gene increased, while the expression of Hgf gene was not detected upon long-term suppression of gastric acid secretion of hydrochloric acid by omeprazole that indicated possible development of liver fibrosis. Abovementioned parameters were only partially restored to control values in the case of simultaneous administration of multiprobiotic “Symbiter® acidophilic” concentrated with omeprazole, thus indicating the ability of this preparation to counteract the development of oxidative damages in liver tissues upon long-term gastric hypoacidic conditions.
Stress-responsive systems in rat pancreas upon long-term gastric hypochlorhydria and administration of multiprobiotic “Symbiter®”
K. O. Dvorshchenko, S. Ye. Vakal, A. S. Dranitsina, S. A. Senin, L. I. Ostapchenko
Taras Shevchenko National University of Kyiv, Ukraine;
e-mail: k21037@gmail.com
The intensity of free-radical processes upon long-term omeprazole-induced hypoacidity in the rat pancreas was investigated. Significant violation of oxidative-antioxidative balance in pancreatic tissue upon gastric hypochlorhydria was established: overproduction of superoxide anion, quantitative changes of lipid functional groups, increased level of lipid peroxidation products, augmentation of xanthine oxidase, superoxide dismutase and glutathione transferase activity, as well as depletion of catalase, glutathione peroxidase activity and reduced glutathione content. The inflected expression of Cckbr gene in the rat pancreas upon these conditions was also observed, thus suggesting an increased risk of pathological changes development in the gland. Abovementioned parameters were only partially restored to control values in the case of simultaneous administration of multiprobiotic “Symbiter®” with omeprazole, thus indicating the ability of this preparation to efficiently counteract the development of oxidative damages in pancreatic tissues upon long-term hypoacidic conditions.