R. P. Vynogradova, I. Yu. Chernysh, V. M. Danilova

Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv;
e-mail: valdan@biochem.kiev.ua

The article is devoted to the analysis of the scientific and practical activity of the laboratory of the signaling mechanisms of the cells of the Palladin Institute of Biochemistry, NAS of Ukraine, in the context of the history of its development. The most important results of studies of the mechanisms controlling proliferation, migration and invasion of tumor cells, which testify to the important role of the Ruk/CIN85 adapter protein in carcinogenesis, are presented. These studies are a priority and can serve as an experimental basis for the development of new generation pharmacological agents, the targets for which can be key centers for the organization of signaling systems of the cell – adapter and scaffold proteins.