Ukr.Biochem.J. 2014; Volume 86, Issue 1, Jan-Feb, pp. 111-116

doi: http://dx.doi.org/10.15407/ubj86.01.111

Correction by vitamin D(3) of disturbed metabolism in patients with diabetes mellitus types 1 and 2

04.06.2015   Uncategorized   No comments

Yu. I. Komisarenko

A. A. Bogomolets National Medical University, Kyiv, Ukraine;
e-mail: julia_komissarenko@hotmail.com

Vitamin D deficiency is an increasingly recognized public health problem of population as a whole and against a background of different chronic diseases. The aim of the study was to determine the status of D-vitamin, mineral, carbohydrate and lipid metabolism in patients with diabetes 1 and 2 types and in the case of vitamin D3 application. The data on the impact of vitamin D3 deficiency on mine­ral, carbohydrate and lipid metabolism, as well as on pancreatic β-cells functional activity in patients with diabetes mellitus types 1 and 2 are presented. Certain reasons that lead to the disruption of vitamin D3 metabolism in patients with diabetes mellitus and the results of vitamin D3 application in clinics are discussed.

Keywords: , , ,

References:

  1. Dovidnyk osnovnykh pokaznykiv diialnosti endokrynolohichnoi sluzhby Ukrainy za 2011 rik . Endokrynologia. 2012;17(1). Suppl.2:36.
  2. Chowdhury TA, Lasker SS. Complications and cardiovascular risk factors in South Asians and Europeans with early-onset type 2 diabetes. QJM. 2002 Apr;95(4):241-6. PubMed, CrossRef
  3. Wilmot EG, Edwardson CL, Achana FA, Davies MJ, Gorely T, Gray LJ, Khunti K, Yates T, Biddle SJ. Sedentary time in adults and the association with diabetes, cardiovascular disease and death: systematic review and meta-analysis. Diabetologia. 2012 Nov;55(11):2895-905. PubMed,  CrossRef
  4. Banerjee C, Moon YP, Paik MC, Rundek T, Mora-McLaughlin C, Vieira JR, Sacco RL, Elkind MS. Duration of diabetes and risk of ischemic stroke: the Northern Manhattan Study. Stroke. 2012 May;43(5):1212-7. PubMed, PubMedCentral, CrossRef
  5. Dorohoi A.P. Life expectancy, the potential loss of working capacity and age-specific mortality upon diabetes : Dynamics of feartures. Int. J. Endocrin. 2007;(3(9)):14-19.
  6. Icks A, Claessen H, Morbach S, Glaeske G, Hoffmann F. Time-dependent impact of diabetes on mortality in patients with stroke: survival up to 5 years in a health insurance population cohort in Germany. Diabetes Care. 2012 Sep;35(9):1868-75. PubMed, PubMedCentral, CrossRef
  7. Xu J, Lee ET, Peterson LE, Devereux RB, Rhoades ER, Umans JG, Best LG, Howard WJ, Paranilam J, Howard BV. Differences in risk factors for coronary heart disease among diabetic and nondiabetic individuals from a population with high rates of diabetes: the Strong Heart Study. J Clin Endocrinol Metab. 2012 Oct;97(10):3766-74. PubMed, PubMedCentral, CrossRef
  8. Rhodes ET, Prosser LA, Hoerger TJ, Lieu T, Ludwig DS, Laffel LM. Estimated morbidity and mortality in adolescents and young adults diagnosed with Type 2 diabetes mellitus. Diabet Med. 2012 Apr;29(4):453-63. PubMed, CrossRef
  9. James WP. 22nd Marabou Symposium: the changing faces of vitamin D. Nutr Rev. 2008 May;66(5):286-90. PubMed, CrossRef
  10. Panda DK, Miao D, Tremblay ML, Sirois J, Farookhi R, Hendy GN, Goltzman D. Targeted ablation of the 25-hydroxyvitamin D 1alpha -hydroxylase enzyme: evidence for skeletal, reproductive, and immune dysfunction. Proc Natl Acad Sci USA. 2001 Jun 19;98(13):7498-503.PubMed, PubMedCentral, CrossRef
  11. Hyppönen E, Läärä E, Reunanen A, Järvelin MR, Virtanen SM. Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study. Lancet. 2001 Nov 3;358(9292):1500-3. PubMed, CrossRef
  12. Rojas-Rivera J, De La Piedra C, Ramos A, Ortiz A, Egido J. The expanding spectrum of biological actions of vitamin D. Nephrol Dial Transplant. 2010 Sep;25(9):2850-65. Review. PubMed, CrossRef
  13. Pozzilli P, Manfrini S, Crinò A, Picardi A, Leomanni C, Cherubini V, Valente L, Khazrai M, Visalli N; IMDIAB group. Low levels of 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 in patients with newly diagnosed type 1 diabetes. Horm Metab Res. 2005 Nov;37(11):680-3. PubMed, CrossRef
  14. Maiyar AC, Norman AW. Enciclopedia of Human Biology. London: Acad. Press,  1991; 7:859–871.
  15. Zella JB, McCary LC, DeLuca HF. Oral administration of 1,25-dihydroxyvitamin D3 completely protects NOD mice from insulin-dependent diabetes mellitus. Arch Biochem Biophys. 2003 Sep 1;417(1):77-80. PubMed, CrossRef
  16. Bodnar P.M., Mykhalchyshyn H.P., Komisarenko Iu.I. et al. Endokrynologia. Vinnytsya: Nova Knyha Publishers, 2013. 480 p.
  17. Katz M. H. Study Design and Statistical Analysis. Cambridge: University Press, 2009.  188 р.
  18. Novikov D. A., Novochadov V. V. Statisticheskie metody v mediko-biologicheskom eksperimente (tipovyie sluchai). Volgograd: VolGMU, 2005. 84 p.
  19. Holick M. F. Nutrition and Health. New York: Humana Press, 2010. 1155 p.
  20. Gómez Alonso C, Naves Díaz M, Rodríguez García M, Fernández Martín JL, Cannata Andía JB. Review of the concept of vitamin D “sufficiency and insufficiency”. Nefrologia. 2003;23 Suppl 2:73-7. Review. Spanish. PubMed
  21. Holick MF. Vitamin D status: measurement, interpretation, and clinical application. Ann Epidemiol. 2009 Feb;19(2):73-8. Review. PubMed, PubMedCentral, CrossRef
  22. Grineva EN, Karonova T, Micheeva E, Belyaeva O, Nikitina IL. Vitamin D deficiency is a risk factor for obesity and diabetes type 2 in women at late reproductive age. Aging (Albany NY). 2013 Jul;5(7):575-81. PubMed, PubMedCentral
  23. Adams JS, Hewison M. Update in Vitamin D. J Clin Endocrinol Metab. 2010 Feb; 95(2): 471–478.  PubMedCentral, CrossRef
Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License.