Ukr.Biochem.J. 2015; Volume 87, Issue 4, Jul-Aug, pp. 37-44


Hepatoprotective activity of exogenous RNA

 I. O. Shmarakov1, Т. V. Marchyshak1, V. L. Borschovetska1,
M. M. Marchenko1, Z. Yu. Tkachuk2

1Yuriy Fedkovych Chernivtsi National University, Ukraine;
2Institute of Molecular Biology and Genetics,
National Academy of Sciences of Ukraine, Kyiv;

Hepatoprotective activity of Nuclex, a pharmaceutical composed of low-molecular yeast RNA, was investigated during acute and chronic thioacetamide-induced hepatotoxicity. It is demonstrated, that Nuclex administration at a dose of 200 mg/kg during acute and chronic liver injury produces hepatoprotective effect, which is associated with decrease in liver parenchyma lesions and in its inflammatory infiltration. Nuclex application attenuates thioacetamide-induced free radical damage of hepatic biopolymers, expressed in the reduction of TBA-reactive products, carbonyl derivatives, and recovery of protein thiol groups and reduced glutathione levels.

Keywords: , , , ,


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