Ukr.Biochem.J. 2015; Volume 87, Issue 4, Jul-Aug, pp. 37-44

doi: https://doi.org/10.15407/ubj87.04.037

Hepatoprotective activity of exogenous RNA

23.07.2015   Uncategorized   No comments

 I. O. Shmarakov1, Т. V. Marchyshak1, V. L. Borschovetska1,
M. M. Marchenko1, Z. Yu. Tkachuk2

1Yuriy Fedkovych Chernivtsi National University, Ukraine;
е-mail: igor.shmarakov@gmail.com;
2Institute of Molecular Biology and Genetics,
National Academy of Sciences of Ukraine, Kyiv;
е-mail: ztkachuk@yahoo.com

Hepatoprotective activity of Nuclex, a pharmaceutical composed of low-molecular yeast RNA, was investigated during acute and chronic thioacetamide-induced hepatotoxicity. It is demonstrated, that Nuclex administration at a dose of 200 mg/kg during acute and chronic liver injury produces hepatoprotective effect, which is associated with decrease in liver parenchyma lesions and in its inflammatory infiltration. Nuclex application attenuates thioacetamide-induced free radical damage of hepatic biopolymers, expressed in the reduction of TBA-reactive products, carbonyl derivatives, and recovery of protein thiol groups and reduced glutathione levels.

Keywords: , , , ,

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