Ukr.Biochem.J. 2012; Volume 84, Issue 2, Mar-Apr, pp. 42-47

Activity of enzymatic detoxification systems in the mice liver under conditions of different retinoid provision

М. M. Marchenko, G. P. Kopylchuk, I. O. Shmarakov, I. M. Buchkovska

Yuriy Fedkovych Chernivtsi National University, Ukraine;

The activity of cellular components of liver detoxification system was studied under the conditions of the absence of vitamin A stores. It is shown that a decrease of p-hydroxylase and N-demethylase activity of cytochrome P-450 simultaneously with a decrease of glutathione-S-transferase activi­ty takes place in the liver microsomal fraction of vitamin A-deficient animals. At the same time the absence of retinoid stores in knock-out animals influences the decrease of only p-hydroxylase activity of cytochrome P-450 system. The increase in glutathione-S-transferase activity is observed in the liver postmicrosomal fraction in mice, kept on vitamin A-deficient diet, while its parametres in knock-out group animals were not statistically different compared to the control.

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