Ukr.Biochem.J. 2016; Volume 88, Issue 3, May-Jun, pp. 99-105

doi: https://doi.org/10.15407/ubj88.03.099

Hepatotoxicity of bisphenol A under conditions of differential supplementation with retinoids

I. O. Shmarakov, V. L. Borschovetska, L. P. Ivanishchuk, M. M. Marchenko

Yuriy Fed’kovych Chernivtsi National University, Ukraine;
e-mail: igor.shmarakov@gmail.com

Classical xenoestrogenic in vivo effects of bisphenol A (2,2-bis(4-hydroxyphenyl)propane, BPA) are well-described in the literature, however the molecular mechanisms of BPA-induced hepatotoxicity are not fully characterized. The work is aimed to assess biochemical markers of BPA induced hepatotoxicity under conditions of differential supplementation with retinoids. We demonstrate that the absence of hepatic retinyl esters as the main form of vitamin A storage provides for a resistance to BPA induced liver damage. Retinoid supplementation increases the hepatotoxic effects of bisphenol A, evidenced in higher indexes of oxidative damage of lipids, proteins and non-protein thiol groups as well as increase of serum alanine  aminotransferase activity and myeloperoxidase activity in liver parenchyma. The absence of hepatotoxicity signs when hepatic retinoid stores are depleted and their presence during normal or excessive retinoid supplementation suggest that hepatic retinoid availability is one of the factors determining the hepatotoxicity of bisphenol A.

Keywords: , , ,


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