Ukr.Biochem.J. 2017; Volume 89, Issue 4, Jul-Aug, pp. 49-55


The experimental investigation of fibrinolytic system under the influence of flocalin in conditions of acute hypoxic kidney injury

A. I. Gozhenko1, Yu. I. Gubsky2, N. D. Filipets3,
О. О. Filipets3, O. A. Gozhenko1

1State Enterprise Ukrainian Research Institute for Medicine of Transport, Odessa;
2State Institution Institute of Pharmacology and Toxicology, National Academy of Medical Sciences of Ukraine, Kyiv;
3Higher State Educational Establishment of Ukraine Bukovinian State Medical University, Chernivtsi;

In the experiments on rats subjected to acute hypoxic histochemical nephropathy, caused by sodium nitrite and 2,4-dinitrophenol, fibrinolytic activities of blood plasma, urine, renal cortex, medulla, and papilla after treatment with flocalin – the activator of KATP channels, were studied­. It was shown that in the conditions of acute kidney hypoxic injury flocalin administration resulted in the increase and essential restoration of fibrinolysis in blood plasma diminished under hypoxia, which was due to the growth of non-enzymatic fibrinolysis, whereas in urine and renal medulla the appreciable increase of enzymatic fibrinolytic activity took place. Moreover, the treatment of hypoxic nephropathy animals by flocalin resulted in the marked restoration of kidney ion regulatory and protein excretory functions that proves the positive influence of KATP channels activation on the one of the biochemical mechanisms of acute kidney injury as well as the protective effect of flocalin in relation to tubular cells of nephron. The obtained results testify to the beneficial effects of KATP channels activation in the conditions of acute hypoxic kidneys injury.

Keywords: , ,


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