Ukr.Biochem.J. 2025; Volume 97, Issue 4, Jul-Aug, pp. 110-119

doi: https://doi.org/10.15407/ubj97.04.110

The unsung hero of science: Barbara McClintock, who won the Nobel Prize in Physiology or Medicine in 1983 for her discovery of mobile genetic elements

10.09.2025   Uncategorized   No comments

O. P. Matyshevska*, M. V. Grigorieva, S. V. Komisarenko

Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv;
*e-mail: matysh@yahoo.com

Received: 17 July 2025; Revised: 25 August 2025;
Accepted: 12 September 2025; Available on-line: 18 September 2025

In 1983, American plant biologist and cytogeneticist McClintock, one of the great loners of modern­ scien­ce, received the first woman scientist’s unshared Nobel Prize in Physiology or Medicine. Barbara McClintock’s research, conducted in the 1930s, long before the structure of DNA was deciphered, included creating­ the first genetic map of ten chromosomes composing the haploid set of maize microspores and cytological determination of gene location within individual chromosomes. Two phenomena with which Barbara McClintock’s name will forever be associated are crossing over and transposons. Her finding that chromosomes might exchange physical parts as part of gene exchange confirmed Morgan’s theory of inheritance. Experiments in 1940-1950s with the phenotypes of hybrid maize kernels led her to the concept that genetic elements, which she referred to as Dissociation and Activator controling elements, could transpose and regulate the genes by inhibiting or modulating their action. Her revolutionary findings were ahead of their time, in conflict with the established concept of a stable genome and met with scepticism and opposition. Much later, the scientific world accepted her ideas on mobile genetic elements, and it was recognition she appreciated but never sought. McClintock considered the genome as a highly sensitive organ that responds to unexpected events, often by genome restructuring, which scientists today are trying to understand. In this review, the scien­tific path and achievements of Barbara McClintock are analyzed.

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References:

  1. Barbara McClintock. Regime of access : https://en.wikipedia.org/wiki/Barbara_McClintock.
  2. Comfort NC. The Tangled Field: Barbara McClintock’s Search for the Patterns of Genetic Control. Harvard University Press, 2001. 368 p.
  3. Reynolds MD. American women scientists: 23 inspiring biographies, 1900–2000. McFarland Company, 1999.
  4. Barbara McClintock in cornfield. Regime of access: https://diglib.amphilsoc.org/islandora/object/barbara-mcclintock-cornfield-postcard.
  5. McClintock Barbara. Biographical. Regime of access: https://www.nobelprize.org/prizes/medicine/1983/mcclintock/biographical/
  6. Kass LB. Records and recollections: a new look at Barbara McClintock, Nobel-Prize-winning geneticist. Genetics. 2003;164(4):1251-1260. PubMed, PubMed, CrossRef
  7. Randolph LF, McClintock B. Polyploidy in Zea mays L. Am Nat. 1926;60(666):99-102.
  8. Campbell A. Barbara McClintock. Annu Rev Genet. 1993;27:1-32. CrossRef
  9. Barbara McClintock: Jumping Gene Pioneer – Perseverance in Face of Skepticism. Regime of access : https://editverse.com/barbara-mcclintock-transposons-scientific-skepticism/
  10. Wayne R. Identifying the Individual Chromososmes of Maize. In: Perspectives on Nobel Laureate Barbara McClintock’s Publications (1926-1984): A Companian Volume. Ed. Lee B. Kaas. Internet-First University Press, 2016-10-24. Regime of access: http://labs.plantbio.cornell.edu/wayne/pdfs/kass-wayne2.pdf.
  11. McClintock B. Chromosome Morphology in Zea mays. Science. 1929;69(1798):629. PubMed, CrossRef
  12. McClintock B, Hill HE. The Cytological Identification of the Chromosome Associated with the R-G Linkage Group in ZEA MAYS. Genetics. 1931;16(2):175-190. PubMed, PubMed, CrossRef
  13. McClintock B. The Order of the Genes C, Sh and Wx in Zea Mays with Reference to a Cytologically Known Point in the Chromosome. Proc Natl Acad Sci USA. 1931;17(8):485-491. PubMed, PubMed, CrossRef
  14. McClintock B.A cytological demonstration of the location of an interchange between two non-homologous chromosomes of Zea mays. Proc Natl Acad Sci USA. 1930;16(12):791-796. PubMed, PubMed, CrossRef
  15. Creighton HB, McClintock B. A Correlation of Cytological and Genetical Crossing-Over in Zea Mays. Proc Natl Acad Sci USA. 1931;17(8):492-497. PubMed, PubMed, CrossRef
  16. Coe E, Kass LB. Proof of physical exchange of genes on the chromosomes. Proc Natl Acad Sci USA. 2005;102(19):6641-6646.
    PubMed, PubMed, CrossRef
  17. Biography 32: Barbara McClintock (1902 -1992). Regime of access: https://dnalc.cshl.edu/view/16685-Biography-32-Barbara-McClintock-1902-1992-.html.
  18. Kass LB. Missouri compromise: tenure or freedom. New evidence clarifies why Barbara McClintock left Academe. Maize Genetics Cooperation Newsletter. 2005;(79):52-71.
  19. Comfort NC. Barbara McClintock’s long postdoc years. Science. 2002;295(5554):440. PubMed, CrossRef
  20. Barbara McClintock. Regime of access : https://www.nobelprize.org/stories/women-who-changed-science/barbara-mcclintock
  21. Controlling Elements: Cold Spring Harbor, 1942–1967. The Barbara McClintock Papers, Profiles in Science, National Library of Medicine. Retrieved March 2, 2013.
  22. Fedoroff NV. McClintock’s challenge in the 21st century. Proc Natl Acad Sci USA. 2012;109(50):20200-2023. PubMed, PubMed, CrossRef
  23. Barbara McClintock and the discovery of jumping genes (transposons). Regime of access :
    https://www.nature.com/scitable/topicpage/barbara-mcclintock-and-the-discovery-of-jumping-34083/
  24. McClintock B. The origin and behavior of mutable loci in maize. Proc Natl Acad Sci USA. 1950;36(6):344-355. PubMed, PubMed, CrossRef
  25. Matyshevska OP, Danilova VM, Komisarenko SV. The discovery of the DNA double helix, or the revolution that ushered in the era of molecular biology (Nobel Prize 1962). Ukr Biochem J. 2020;92(6):183-198. CrossRef
  26. McClintock B. Some parallels between gene control systems in maize and in bacteria. Am Nat. 1961;95(884):265-277. CrossRef
  27. Matyshevska OP, Danilova VM, Komisarenko SV. The discovery of genetic control of enzyme and virus synthesis: 1965 Nobel Prize Laureates André Lwoff, François Jacob, Jacques Monod. Ukr Biochem J. 2021;93(4):111-119. CrossRef
  28. McClintock B. Chromosome organization and genic expression. Cold Spring Harb Symp Quant Biol. 1951;16:13-47. PubMed, CrossRef
  29. Witkin EM. Chances and choices: Cold Spring Harbor 1944-1955. Annu Rev Microbiol. 2002;56:1-15. PubMed, CrossRef
  30. Fedoroff NV. Barbara McClintock. In: Biographical Memoirs. National Academies Press, 1995. Biographical Memoirs: Volume 68. Washington, DC: The National Academy Press, Washington, DC, 1995. Vol. 68:211-236. CrossRef
  31. Barbara McClintock: A-“maizing” Insights about Jumping Genes. Regime of access: https://laskerfoundation.org/barbara-mcclintock-a-maizing-insights-about-jumping-genes/
  32. Barbara McClintock Seminar Series. Regime of access: https://www.mpipz.mpg.de/5411813/McClintock.
  33. Lander ES, Linton LM, Birren B, Nusbaum C, Zody MC, Baldwin J, Devon K, Dewar K, Doyle M, FitzHugh W. et al. Initial sequencing and analysis of the human genome. Nature. 2001;409(6822):860-921. PubMed, CrossRef
  34. Fedoroff N, Wessler S, Shure M. Isolation of the transposable maize controlling elements Ac and Ds. Cell. 1983;35(1):235-242. PubMed, CrossRef
  35. Transposon. Regime of access: https://www.britannica.com/science/transposon.
  36. Transposable element. Regime of access: https://en.wikipedia.org/wiki/Transposable_element .
  37. Comfort NC. From controlling elements to transposons: Barbara McClintock and the Nobel Prize. Trends Biochem Sci. 2001;26(7):454-457. pm id=”11440859″], CrossRef
  38. Pray LA. Transposons: The Jumping Genes. Nature Educ. 2008;1(1):204.
    Regime of access: https://www.nature.com/scitable/topicpage/transposons-the-jumping-genes-518/
  39. Barbara McClintock – Nobel Prize lecture. Regime of access: https://www.nobelprize.org/prizes/medicine/1983/mcclintock/lecture/
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