N. S. Shevchenko, N. V. Krutenko*, T. V. Zimnytska, K. V. Voloshyn

V. N. Karazin Kharkiv National University, Department of Pediatrics No. 2,Ukraine;
*e-mail: n.v.krutenko@karazin.ua

Received: 13 October 2020; Accepted: 07 July 2021

This review highlights the current understanding of hypoxia-inducible factors (HIFs) role as regulators of oxygen-dependent reactions and inducers of genes expression in  human organism. The focus is on the most significant relationships between the activation or inhibition of the HIFs intracellular system and development of the inflammatory process in various organs, chronic diseases of gastrointestinal tract, osteoarticular system, kidneys as well as  hematological, endocrine and metabolic disorders.