Tag Archives: coronary artery disease

Plasma amino acids pecularities and cardiometabolic risk factors in patients with coronary artery disease and atrial fibrillation

11.12.2023   Uncategorized   No comments

I. O. Melnychuk*, M. L. Sharayeva, O. V. Dolynna,
O. V. Savchenko, V. N. Kramarova, V. H. Lyzogub

Bogomolets National Medical University, Kyiv, Ukraine;
*e-mail: ira.merkulova45@gmail.com

Received: 06 September 2023; Revised: 06 November 2023;
Accepted: 01 December 2023; Available on-line: 18 December 2023

Studies targeting small molecule metabolites (amino acids, sugars, nucleotides, lipids) in connections with gut microbiota metabolites that impact the host metabolome give a possibility to define a special metabolic signature of different diseases. Plasma amino acids (AA) profile is known to be a new promising biomarker for the screening of coronary artery disease (CAD) pathogenesis connected with gut dysbiosis. The aim of our study was to estimate the spectrum of plasma amino acids in CAD patients with atrial fibrillation (AF) and to check their connections with the gut microbiota metabolites. 300 patients were divided into three groups: CAD – 149 patients with CAD but without arrhythmias, CAD+AF – 123 patients with CAD and AF paroxysm and control group– 28 patients without CAD and arrhythmias. Plasma AA level was detected by ion exchange liquid column chromatography. Significant changes in the content of plasma Glutamate, Glutamine, Glycine, Alanine, Valine and Tyrosine and combinations Isoleucine+Leucine/Valine, Glycine+Serine, Glycine/Methionine, Phenylalanine/Tyrosine, Glutamine/Glutamate in CAD+AF patients were detected. A strong reliable connection between plasma AA spectrum and gut microbiota metabolites trimethylamine, trimethylamine-N-oxide and total amount of fecal short chain fatty acids was determined. The highly validated plasma AA combinations Isoleucine – Glycine (area under ROC-curve 0.8122) and Phenylalanine – Glycine (area under ROC-curve 0.8061) that can be used as the early markers of AF paroxysm in CAD patients were proposed.

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Lipid parameters in the blood of coronary artery diseases patients depending on age and dietary components: a case study

03.11.2022   Uncategorized   No comments

S. Prasad1, M. K. Mishra2*, A. K. Yadav2

1Department of Biochemistry, K. J. Somaiya Medical College and Research Mumbai, India;
2Department of Biochemistry, Shri Ramakrishna Institute of Medical Science
and Sanaka Hospitals, Durgapur, West Bengal, India;
*e-mail: mritunjaymishra007@gmail.com

Received: 19 March 2022; Revised: 13 September 2022;
Accepted: 04 November 2022; Available on-line: 14 November 2022

Coronary artery disease (CAD) is the major cause of mortality worldwide and is defined as an elevated level of atherogenic cholesterol and low levels of HDL cholesterol. However, very few studies have been conducted in India on the association of blood lipid profile with age and diet. The study aims to estimate lipid parameters in the blood of CAD patients aged 40-70 years on different diets. Lipid parameters were analyzed by enzymatic method on EM-200 fully automated Biochemistry analyzer. The data obtained showed that the majority of patients who suffered from CAD were between the age group of 51-60 years. Patients with CAD had altered lipid profiles, with higher levels of serum TGs, total cholesterol and low levels of HDL. Vegetarians have been found to have reduced lipid risk factors for coronary heart disease compared to patients on a mixed diet.

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