Tag Archives: cytokine

Inclusion of enterosorbents in anti-inflammatory therapy improve treatment effectiveness in copd patients during exacerbations

S. V. Kucher*, O. V. Lototska

I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine;
*e-mail: kuchersv@tdmu.edu.ua

Received: 29 January 2021; Accepted: 23 April 2021

Inflammation plays a key role in the development of chronic obstructive pulmonary disease (COPD), and manifests as increased levels of inflammation markers such as cytokines. The purpose of this study was to examine the effect of enterosorbents on IL-1β, TNF-α and IL-10 levels in COPD patients with exacerbations, while taking into account their ages. Patients were divided into two age groups: age group 1 (40-59 years) and age group 2 (>60 years). Levels of IL-1β, TNF-α and IL-10 were determined by enzyme-linked immunosorbent assay. Levels of pro-inflammatory and anti-inflammatory cytokines were increased in both age groups of COPD patients during exacerbations compared to the healthy control group. Pro-inflammatory cytokines (IL-1β, TNF-α) increased more in age group 2. Basic therapy (BT) had positive impacts. Addition to BT of the enterosorbents Enterosgel and Carboline decreased serum levels of IL-1β, TNF-α and IL-10 in both age groups more than after BT alone. Greater changes were observed in age group 2. We found that addition of the enterosorbents Carboline or Enterosgel to basic therapy of COPD patients during exacerbations decreased levels of IL-1β, TNF-α and IL-10 in patients of both age groups (40-59 years and >60 years).

The content of pro-inflammatory cytokines IL-1β, IL-6, IL-17A and TNFα in the blood of patients with type 2 diabetes after therapy with metformin

K. P. Zak*, O. V. Furmanova, V. V. Popova, Ya. A. Sayenko

SI “V.P. Komisarenko Institute of Endocrinology and Metabolism of National Academia of Medical Sciences of Ukraine”, Kyiv;
*e-mail: kpzak2017@gmail.com

Received: 28 February 2020; Accepted: 13 November 2020

Currently the world society is extremely worried about the global increase in the number of patients with diabetes on our planet. Annually 4 million people die of this disease, and the cost of its treatment reaches trillions of dollars. A new highly effective oral antidiabetic drug  metformin (1,1-dimethylbiguanide hydrochloride) is one of the most common hypoglycemic remedies  currently prescribed for the first-line treatment of patients with type 2 diabetes (T2D). However, the mechanism of its curative effect is still not clear. The results of our study showed  that metformin treatment of patients with newly diagnosed T2D was followed by  pronounced normalization of  the increased levels of pro-inflammatory cytokines (IL-1β, IL-6, IL-17A and TNFα),  inflammation indexes and lymphocyte’s immunophenotype. The obtained data confirm the existing hypothesis about the inflammatory nature of T2D and indicate that the immune system, in particular proinflammatory cytokines, plays a significant role in the mechanism of the curative effect of metformin at  T2D.

Changes in content of glycolipids, sphingosine and cytokines in the rat brain with experimental edema

G. V. Zakaryan

M. Heratsi Yerevan State Medical University, Yerevan, Armenia;
e-mail: gayane.zak@gmail.com

The study of the content of cerebrosides, gangliosides and their hydrolytic degradation product­ – sphingosine in the rat brain with experimental edema was carried out. In parallel, the cytokine profile of pro- and anti-inflammatory cytokines in the blood of rats with experimental cereb­ral edema was studied.
The experiments indicated that a decrease of the total fraction of glycolipids and an increase of sphingosine content in the brain of rats with brain swelling were observed. The development of brain edema was accompanied by the increase in pro-inflammatory and decrease in anti-inflammatory cytokine content.