S. V. Komisarenko

Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine,
Department of Molecular Immunology, Kyiv;
e-mail: svk@biochem.kiev.ua

Received:   2025; Revised: 2025; Accepted: 2025

The Department of Molecular Immunology was established in September 1975. Since its founding, the Department has focused on two main areas of research: 1) investigating the mechanisms underlying the biological, in particular immunotropic and antitumor, effects of organophosphorus derivatives of inorganic pyrophosphate, and 2) developing and applying methods of immunochemical analysis of proteins to determine the molecular mechanisms of antigen recognition by the immune system. Over the years, the Department has developed a number of antitumor immunotoxins, studied intracellular signaling mechanisms in lymphocytes, revealed an adverse effect of low-dose radiation on the “natural” immune system in Chernobyl accident liquidators, and explored the immunochemical structures of the neurotoxin apamin, cytochrome c, fibrinogen, and fibrin molecules. Since 2020, the research of the Department has focused on various aspects of ensuring national security and defense, particularly in response to the large-scale COVID-19 pandemic caused by the SARS-CoV-2 coronavirus, and on developing potential therapeutic agents for the complex treatment of PTSD and injuries, which are crucial during large-scale warfare.