Tag Archives: receptors

Protein expression of estrogen, progesterone, and human epidermal growth factor receptors in young Iraqi women with breast cancer

16.10.2024   Uncategorized   No comments

K. A. Al-Hilali1*, R. Q. Aljawher2, S. A. Faris3

1Directorate of Education in Thi-Qar, Thi-Qar, Iraq;
2College of Medicine University of Thi-Qar, Thi-Qar, Iraq;
3College of Education for Pure Since- University of Thi-Qar, Thi-Qar, Iraq;
*e-mail: khadijaaziz711@gmail.com

Received: 13 April 2024; Revised: 24 June 2024;
Accepted: 07 October 2024; Available on-line: 28 October 2024

Breast cancer is currently evaluated by the presence of hormonal receptors in the tumor tissue, which are among the most important prognostic and predictive markers used at present. The current study was conducted in Thi-Qar Governorate (Iraq) on women aged 20-40 years who have breast cancer (BC), highlighting­ the spread of this disease among young groups. The expression of estrogen (ER), progesterone (PR), and human epidermal growth factor (Her2/neu) receptors in breast tissues using immunohistochemical analysis was estimated. Breast tissue samples were collected from patients undergoing breast surgery and biopsy. Formalin-fixed paraffin-embedded samples were divided into BC (80), and control (20) groups. The study found that protein expression of both ER and PR was positive in 87.5% and negative in 12.5%, Her2/neu positive in 60% and negative in 40% of BC samples. The subtypes identified were luminal A (58.75%), luminal B (31.25%), HER2-positive (6.25%), and triple-negative (3.75%) BC. The high percentage of luminal A molecular subtype of BC is considered a good prognosis and treatable by anti-hormonal therapy.

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Sphingosine-1-phosphate: distribution, metabolism and role in the regulation of cellular functions

27.07.2015   Uncategorized   No comments

V. I. Morozov1, G. A. Sakuta2, M. I. Kalinski3

1Sechenov Institute of Evolutionary Physiology and Biochemistry
of the Russian Academy of Sciences, St. Petersburg, Russia;
e-mail: vmorozov.g@gmail.com;
2Institute of Cytology of the Russian Academy of Sciences, St. Petersburg, Russia;
3Kent State University, Kent, OH, USA

The role of sphingosine-1-phosphate (S1P) in regulation of cellular functions and cell protection is reviewed. S1P, along with other sphingolipid metabolites, is believed to act as an intracellular second messenger and as an extracellular mediator molecule. S1P chemistry, production and metabolism are described. Cellular receptors for S1P and their tissue specificity are described. Platelets and erythrocytes have a crucial significance in blood transport of S1P. Hypoxic conditions induce an increase in S1P, which initiates a set of cytoprotective events via its cellular receptors. S1P involvement in regulation of cell migration, myogenesis, control of skeletal muscle function is described. It is shown that S1P balance disturbances may mediate pathological state. S1P system implication in regulation of the most important cellular functions allows considering it as a prospective remedial target.

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