Tag Archives: signal transduction
Heparin-binding EGF-like growth factor: mechanisms of biological activity and potential therapeutic applications
L. M. Dronko1, T. M. Lutsenko1*, N. V. Korotkevych2,
I. O. Vovk2, D. A. Zhukova2, S. I. Romaniuk2,
A. A. Siromolot2, A. J. Labyntsev2, D. V. Kolybo2
1National Technical University of Ukraine “Igor Sikorsky Kyiv Polytechnic Institute”, Kyiv;
2Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv;
*e-mail: lutsenko.tetiana@lll.kpi.ua
Received: 06 August 2024; Revised: 18 September 2024;
Accepted: 07 October 2024; Available on-line: 28 October 2024
The diphtheria toxin receptor on sensitive mammalian cells is known as the membrane anchored precursor of heparin-binding EGF-like growth factor (HB-EGF). When the precursor is cleaved by metalloproteinases, a soluble form (sHB-EGF) is formed that can bind to the EGF receptors, resulting in activation of signaling pathways that regulate cell proliferation, differentiation, migration, and inhibition of apoptosis. The ability of HB-EGF to cause both positive and negative consequences for organism underscores the complexity of its biological functions and the need for a nuanced understanding of its role in health and disease. In this review the data on the HB-EGF structure, biological activity, involvement in the mechanism of diphtheria toxin action, wound healing, tumor progression as well as the methods of HB-EGF delivery are summarized.
Na(+), K(+)-ATPase, endogenous cardiotonic steroids and their transducing role
O. V. Tsymbalyuk1, S. O. Kosterin2
1Taras Shevchenko Kyiv National University, Ukraine;
2Palladin Institute of Biochemistry, National Academy of Science of Ukraine, Kyiv;
e-mail: otsimbal@univ.kiev.ua
Na+, K+-ATPase – a protein complex of plasmatic membrane, which performs the dual function: firstly, it supports the Na+ and K+ homeostasis, and also transmembrane potential gradient, secondly, it serves as the transducer of signals and as the regulator of the expression of many key genes. Endogenous cardiotonic steroids, which are synthesized in the adrenal glands and hypothalamus, serve as the signal molecules. New concepts about the mechanisms of the realization of the Na+, K+-ATPase signal function and their connection with cellular functions, apoptosis, and with pathologies of cardiovascular system and water-salt homeostasis are described in the survey.