Ukr.Biochem.J. 2014; Volume 86, Issue 5, Sep-Oct, pp. 151-155


Age changes of human serum polyreactive immunoglobulins (PRIG) activity

S. A. Bobrovnik, M. A. Demchenko, S. V. Komisarenko

Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv;

It has been determined that activity of serum polyreactive immunoglobulins (PRIG) changes with age in practically healthy people at the age from twenty five to seventy. Therewith, the activity of serum IgG PRIG increases most of all (about 3-4 times), while IgM PRIG activity, on the contrary, does not increase, but sometimes even decreases with age. IgA PRIG activity varies significantly more than IgG PRIG activity and, besides, IgА PRIG significantly less depends on age than IgG PRIG. The age changes in the activity of human serum PRIG, belonging to different types of immunoglobulins, may evidence for the important functional role of these immunoglobulins that has to be clarified.

Keywords: , ,


  1. Immunoglobulins. Ed. Litman G., Good R. Moscow: Mir, 1981. 496 p. (In Russian).
  2. Buckley CE 3rd, Dorsey FC. The effect of aging on human serum immunoglobulin concentrations. J Immunol. 1970 Oct;105(4):964-72. PubMed
  3. Cassidy JT, Nordby GL, Dodge HJ. Biologic variation of human serum immunoglobulin concentrations: sex-age specific effects. J Chronic Dis. 1974 Dec;27(11-12):507-16. PubMed, CrossRef
  4. Stoica G, Macarie E, Michiu V, Stoica RC. Biologic variation of human immunoglobulin concentration. I. Sex-age specific effects on serum levels of IgG, IgA, IgM and IgD. Med Interne. 1980 Jul-Sep;18(3):323-32. PubMed
  5. Bobrovnik SA. Activation of “silent” antibodies and their interaction with antigens. Ukr Biokhim Zhurn. 1990 Sep-Oct;62(5):86-9. Russian. PubMed
  6. Bobrovnik SA, Liashchenko KP, Komisa­renko SV. Polyspecific antibodies and their activation. Proc. National Acad. Ukraine. 1990;(6):71-74. (In Russian).
  7. Bobrovnik SA, Marinets AV. Properties of polyreactive immunoglobulins. Ukr Biokhim Zhurn. 1993 Sep-Oct;65(5):21-6. Russian. PubMed
  8. Bobrovnik SA. Polyreactive immunoglobulins: molecular properties and functions. Comments Mol. Cell. Biophys. 1999;9:323-356.
  9. Bobrovnik SA. Polyreactive immunoglobulins recognize hydrophobic parts of proteins. Ukr Biokhim Zhurn. 2001 Mar-Apr;73(2):116-22. Russian. PubMed
  10. Bobrovnik SA. Mechanisms of interaction of polyreactive immunoglobulins and protein antigens. Ukr Biokhim Zhurn. 2002 Mar-Apr;74(2):37-44. Russian. PubMed
  11. Bouvet JP, Stahl D, Rose S, Quan CP, Kazatchkine MD, Kaveri SV. Induction of natural autoantibody activity following treatment of human immunoglobulin with dissociating agents. J Autoimmun. 2001 Mar;16(2):163-72. PubMed, CrossRef
  12. Bouvet JP, Quan CP, Dighiero G. Polyreactivity is not an artefact. J Immunol Methods. 2001 Aug 1;254(1-2):199-201. PubMed, CrossRef
  13. Zhou ZH, Tzioufas AG, Notkins AL. Properties and function of polyreactive antibodies and polyreactive antigen-binding B cells. J Autoimmun. 2007 Dec;29(4):219-28. Epub 2007 Sep 20. Review. PubMed, PubMedCentral, CrossRef
  14. Bobrovnik S. A., Starodub N. F. New simple method of antigen immobilization on immunological plates. Immunology (Moscow). 1988;(5):83-85. (In Russian).
  15. Bobrovnik SA, Demchenko MA, Komisarenko SV. Interaction peculiarities of polyreactive immunoglobulins and various antigens. Ukr Biochem J. 2014 Jan-Feb;86(1):68-74. Russian. PubMed

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License.