Ukr.Biochem.J. 2014; Volume 86, Issue 3, May-Jun, pp. 23-32


Structure and functions of glutathione transferases

O. M. Fedets

Stepan Gzhytskyi Lviv National University of Veterinary Medicine and Biotechnologies, Ukraine;

Data about classification, nomenclature, structure, substrate specificity and role of many glutathione transferase’s isoenzymes in cell functions have been summarised. The enzyme has been discovered more than 50 years ago. This family of proteins is updated continuously. It has very different composition and will have demand for system analysis for many years.

Keywords: , , , ,


  1. Commandeur JN, Stijntjes GJ, Vermeulen NP. Enzymes and transport systems involved in the formation and disposition of glutathione S-conjugates. Role in bioactivation and detoxication mechanisms of xenobiotics. Pharmacol Rev. 1995 Jun;47(2):271-330. Review. PubMed
  2. Hopkins FG. On glutathione: A reinvestigation. J. Biol. Chem. 1929;84(1):269–320.
  3. Lu SC. Regulation of glutathione synthesis. Mol Aspects Med. 2009 Feb-Apr;30(1-2):42-59. doi: 10.1016/j.mam.2008.05.005. Epub 2008 Jun 14. PubMed, PubMedCentral, CrossRef
  4. Barnes MM, James SP, Wood PB. The formation of mercapturic acids. 1. Formation of mercapturic acid and the levels of glutathione in tissues. Biochem J. 1959 Apr;71(4):680-90. PubMed, PubMedCentral, CrossRef
  5. Booth J, Boyland E, Sims P. Metabolism of polycyclic compounds. 15. The conversion of naphthalene into a derivative of glutathione by rat-liver slices. Biochem J. 1960 Jan;74:117-22. PubMed, PubMed, CrossRef
  6. Booth J, Boyland E, Sims P. An enzyme from rat liver catalysing conjugations with glutathione. Biochem J. 1961 Jun;79(3):516-24. PubMed, PubMedCentral, CrossRef
  7. Litwack G, Ketterer B, Arias IM. Ligandin: a hepatic protein which binds steroids, bilirubin, carcinogens and a number of exogenous organic anions. Nature. 1971 Dec 24;234(5330):466-7. PubMed, CrossRef
  8. Habig WH, Pabst MJ, Fleischner G, Gatmaitan Z, Arias IM, Jakoby WB. The identity of glutathione S-transferase B with ligandin, a major binding protein of liver. Proc Natl Acad Sci USA. 1974 Oct;71(10):3879-82. PubMed, PubMedCentral, CrossRef
  9. Johnson MK. Metabolism of iodomethane in the rat. Biochem J. 1966 Jan;98(1):38-43. PubMed, PubMedCentral, CrossRef
  10. Boyland E, Chasseaud LF. Glutathione S-aralkyltransferase. Biochem J. 1969 Dec;115(5):985-91. PubMed, PubMedCentral, CrossRef
  11. Grover PL, Sims P. Conjugations with glutathione. Distribution of glutathione S-aryltransferase in vertebrate species. Biochem J. 1964 Mar;90(3):603-6.  PubMed, PubMedCentral, CrossRef
  12. Boyland E, Williams K. An enzyme catalysing the conjugation of epoxides with glutathione. Biochem J. 1965 Jan;94:190-7. PubMed, PubMedCentral, CrossRef
  13. Fjellstedt TA, Allen RH, Duncan BK, Jakoby WB. Enzymatic conjugation of epoxides with glutathione. J Biol Chem. 1973 May 25;248(10):3702-7. PubMed
  14. Hayakawa T, Lemahieu RA, Udenfriend S. Studies on glutathione-S-arene oxidase transferase. A sensitive assay and partial purification of the enzyme from sheep liver. Arch Biochem Biophys. 1974 May;162(1):223-30. PubMed, CrossRef
  15. IUBMB Enzyme Nomenclature [Electronic resource]. Regime of access:
  16. Habig WH, Pabst MJ, Jakoby WB. Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. J Biol Chem. 1974 Nov 25;249(22):7130-9. PubMed
  17. Kamisaka K, Habig WH, Ketley JN, Arias M, Jakoby WB. Multiple forms of human glutathione S-transferase and their affinity for bilirubin. Eur J Biochem. 1975 Dec 1;60(1):153-61. PubMed, CrossRef
  18. Jakoby WB. The glutathione S-transferases: a group of multifunctional detoxification proteins. Adv Enzymol Relat Areas Mol Biol. 1978;46:383-414. Review. PubMed, CrossRef
  19. Bass NM, Kirsch RE, Tuff SA, Marks I, Saunders SJ. Ligandin heterogeneity : evidence that the two non-identical subunits are the monomers of two distinct proteins. Biochim Biophys Acta. 1977 May 27;492(1):163-75. PubMedCrossRef
  20. Mannervik B, Jensson H. Binary combinations of four protein subunits with different catalytic specificities explain the relationship between six basic glutathione S-transferases in rat liver cytosol. J Biol Chem. 1982 Sep 10;257(17):9909-12. PubMed
  21. Jakoby WB, Ketterer B, Mannervik B. Glutathione transferases: nomenclature. Biochem Pharmacol. 1984 Aug 15;33(16):2539-40. PubMed, CrossRef
  22. Mannervik B, Awasthi YC, Board PG, Hayes JD, Di Ilio C, Ketterer B, Listowsky I, Morgenstern R, Muramatsu M, Pearson WR, et al. Nomenclature for human glutathione transferases. Biochem J. 1992 Feb 15;282(Pt 1):305-6. PubMed, PubMedCentral, CrossRef
  23. Mannervik B, Alin P, Guthenberg C, Jensson H, Tahir MK, Warholm M, Jörnvall H. Identification of three classes of cytosolic glutathione transferase common to several mammalian species: correlation between structural data and enzymatic properties. Proc Natl Acad Sci USA. 1985 Nov;82(21):7202-6. PubMed, PubMedCentral, CrossRef
  24. Meyer DJ, Coles B, Pemble SE, Gilmore KS, Fraser GM, Ketterer B. Theta, a new class of glutathione transferases purified from rat and man. Biochem J. 1991 Mar 1;274 ( Pt 2):409-14. PubMed, PubMedCentral, CrossRef
  25. Tomarev SI, Zinovieva RD, Guo K, Piatigorsky J. Squid glutathione S-transferase. Relationships with other glutathione S-transferases and S-crystallins of cephalopods. J Biol Chem. 1993 Feb 25;268(6):4534-42. PubMed
  26. Meyer DJ, Thomas M. Characterization of rat spleen prostaglandin H D-isomerase as a sigma-class GSH transferase. Biochem J. 1995 Nov 1;311 (Pt 3):739-42. PubMed, PubMedCentral, CrossRef
  27. Board PG, Baker RT, Chelvanayagam G, Jermiin LS. Zeta, a novel class of glutathione transferases in a range of species from plants to humans. Biochem J. 1997 Dec 15;328(Pt 3):929-35. PubMed, PubMedCentral, CrossRef
  28. Awasthi YC, Dao DD, Saneto RP. Interrelationship between anionic and cationic forms of glutathione S-transferases of human liver. Biochem J. 1980 Oct 1;191(1):1-10. PubMed, PubMedCentral, CrossRef
  29. Sheehan D, Meade G, Foley VM, Dowd CA. Structure, function and evolution of glutathione transferases: implications for classification of non-mammalian members of an ancient enzyme superfamily. Biochem J. 2001 Nov 15;360(Pt 1):1-16. Review. PubMed, PubMedCentral, CrossRef
  30. Vuilleumier S. Bacterial glutathione S-transferases: what are they good for? J Bacteriol. 1997 Mar;179(5):1431-41. Review. PubMed, PubMedCentral
  31. Toung YP, Hsieh TS, Tu CP. Drosophila glutathione S-transferase 1-1 shares a region of sequence homology with the maize glutathione S-transferase III. Proc Natl Acad Sci USA. 1990 Jan;87(1):31-5. PubMed, PubMedCentral, CrossRef
  32. Tamaki H, Yamamoto K, Kumagai H. Expression of two glutathione S-transferase genes in the yeast Issatchenkia orientalis is induced by o-dinitrobenzene during cell growth arrest. J Bacteriol. 1999 May;181(9):2958-62. PubMed, PubMedCentral
  33. Droog F, Hooykaas P, Van Der Zaal BJ. 2,4-Dichlorophenoxyacetic Acid and Related Chlorinated Compounds Inhibit Two Auxin-Regulated Type-III Tobacco Glutathione S-Transferases. Plant Physiol. 1995 Apr;107(4):1139-1146. PubMed, PubMedCentral
  34. Dixon DP, Davis BG, Edwards R. Functional divergence in the glutathione transferase superfamily in plants. Identification of two classes with putative functions in redox homeostasis in Arabidopsis thaliana. J Biol Chem. 2002 Aug 23;277(34):30859-69. PubMed, CrossRef
  35. Harris JM, Meyer DJ, Coles B, Ketterer B. A novel glutathione transferase (13-13) isolated from the matrix of rat liver mitochondria having structural similarity to class theta enzymes. Biochem J. 1991 Aug 15;278(Pt 1):137-41. PubMed, PubMedCentral, CrossRef
  36. Pemble SE, Wardle AF, Taylor JB. Glutathione S-transferase class Kappa: characterization by the cloning of rat mitochondrial GST and identification of a human homologue. Biochem J. 1996 Nov 1;319(Pt 3):749-54. PubMed, PubMedCentral, CrossRef
  37. Gallagher EP, Gardner JL, Barber DS. Several glutathione S-transferase isozymes that protect against oxidative injury are expressed in human liver mitochondria. Biochem Pharmacol. 2006 May 28;71(11):1619-28. Epub 2006 Apr 17. PubMed, CrossRef
  38. Goto S, Kawakatsu M, Izumi S, Urata Y, Kageyama K, Ihara Y, Koji T, Kondo T. Glutathione S-transferase pi localizes in mitochondria and protects against oxidative stress. Free Radic Biol Med. 2009 May 15;46(10):1392-403. Epub 2009 Mar 6. PubMed, CrossRef
  39. Raza H. Dual localization of glutathione S-transferase in the cytosol and mitochondria: implications in oxidative stress, toxicity and disease. FEBS J. 2011 Nov;278(22):4243-51. Epub 2011 Oct 12. Review. PubMed, PubMedCentral, CrossRef
  40. Morgenstern R, Meijer J, Depierre JW, Ernster L. Characterization of rat-liver microsomal glutathione S-transferase activity. Eur J Biochem. 1980 Feb;104(1):167-74. PubMed, CrossRef
  41. Morgenstern R, Guthenberg C, Depierre JW. Microsomal glutathione S-transferase. Purification, initial characterization and demonstration that it is not identical to the cytosolic glutathione S-transferases A, B and C. Eur J Biochem. 1982 Nov;128(1):243-8. PubMed, CrossRef
  42. Jakobsson PJ, Morgenstern R, Mancini J, Ford-Hutchinson A, Persson B. Common structural features of MAPEG – a widespread superfamily of membrane associated proteins with highly divergent functions in eicosanoid and glutathione metabolism. Protein Sci. 1999 Mar;8(3):689-92. PubMed, PubMedCentral, CrossRef
  43. Jakobsson PJ, Morgenstern R, Mancini J, Ford-Hutchinson A, Persson B. Membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG). A widespread protein superfamily. Am J Respir Crit Care Med. 2000 Feb;161(2 Pt 2):S20-4. Review. PubMed, CrossRef
  44. Rouzer CA, Samuelsson B. The importance of hydroperoxide activation for the detection and assay of mammalian 5-lipoxygenase. FEBS Lett. 1986 Aug 18;204(2):293-6. PubMed, CrossRef
  45. Rouzer CA, Matsumoto T, Samuelsson B. Single protein from human leukocytes possesses 5-lipoxygenase and leukotriene A4 synthase activities. Proc Natl Acad Sci U S A. 1986 Feb;83(4):857-61. PubMed, PubMedCentral, CrossRef
  46. Lam BK, Frank Austen K. Leukotriene C4 synthase. A pivotal enzyme in the biosynthesis of the cysteinyl leukotrienes. Am J Respir Crit Care Med. 2000 Feb;161(2 Pt 2):S16-9. Review.  PubMed, CrossRef
  47. Metters KM, Sawyer N, Nicholson DW. Microsomal glutathione S-transferase is the predominant leukotriene C4 binding site in cellular membranes. J Biol Chem. 1994 Apr 29;269(17):12816-23. PubMed
  48. Lam BK, Penrose JF, Freeman GJ, Austen KF. Expression cloning of a cDNA for human leukotriene C4 synthase, an integral membrane protein conjugating reduced glutathione to leukotriene A4. Proc Natl Acad Sci U S A. 1994 Aug 2;91(16):7663-7. PubMed, PubMedCentral, CrossRef
  49. Mandal AK, Skoch J, Bacskai BJ, Hyman BT, Christmas P, Miller D, Yamin TT, Xu S, Wisniewski D, Evans JF, Soberman RJ. The membrane organization of leukotriene synthesis. Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6587-92. PubMed, PubMedCentral, CrossRef
  50. Scoggan KA, Jakobsson PJ, Ford-Hutchinson AW. Production of leukotriene C4 in different human tissues is attributable to distinct membrane bound biosynthetic enzymes. J Biol Chem. 1997 Apr 11;272(15):10182-7. PubMed, CrossRef
  51. Claesson HE, Haeggström J. Human endothelial cells stimulate leukotriene synthesis and convert granulocyte released leukotriene A4 into leukotrienes B4, C4, D4 and E4. Eur J Biochem. 1988 Apr 5;173(1):93-100. PubMed, CrossRef
  52. Jakobsson PJ, Mancini JA, Riendeau D, Ford-Hutchinson AW. Identification and characterization of a novel microsomal enzyme with glutathione-dependent transferase and peroxidase activities. J Biol Chem. 1997 Sep 5;272(36):22934-9. PubMed, CrossRef
  53. Schmidt-Krey I, Mitsuoka K, Hirai T, Murata K, Cheng Y, Fujiyoshi Y, Morgenstern R, Hebert H. The three-dimensional map of microsomal glutathione transferase 1 at 6 A resolution. EMBO J. 2000 Dec 1;19(23):6311-6. PubMed, PubMedCentral, CrossRef
  54. Morgenstern R, DePierre JW. Microsomal glutathione transferase. Purification in unactivated form and further characterization of the activation process, substrate specificity and amino acid composition. Eur J Biochem. 1983 Aug 15;134(3):591-7.PubMed, CrossRef
  55. Mosialou E, Piemonte F, Andersson C, Vos RM, van Bladeren PJ, Morgenstern R. Microsomal glutathione transferase: lipid-derived substrates and lipid dependence. Arch Biochem Biophys. 1995 Jul 10;320(2):210-6. PubMed, CrossRef
  56. Morgenstern R, Lundqvist G, Hancock V, DePierre JW. Studies on the activity and activation of rat liver microsomal glutathione transferase, in particular with a substrate analogue series. J Biol Chem. 1988 May 15;263(14):6671-5. PubMed
  57. Söderström M, Hammarström S, Mannervik B. Leukotriene C synthase in mouse mastocytoma cells. An enzyme distinct from cytosolic and microsomal glutathione transferases. Biochem J. 1988 Mar 15;250(3):713-8. PubMed, PubMedCentral, CrossRef
  58. Schaffert CS. Role of MGST1 in reactive intermediate-induced injury. World J Gastroenterol. 2011 May 28;17(20):2552-7. Review. PubMed, PubMedCentral, CrossRef
  59. Jakobsson PJ, Thorén S, Morgenstern R, Samuelsson B. Identification of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target. Proc Natl Acad Sci USA. 1999 Jun 22;96(13):7220-5. PubMed, PubMedCentral, CrossRef
  60. Thorén S, Weinander R, Saha S, Jegerschöld C, Pettersson PL, Samuelsson B, Hebert H, Hamberg M, Morgenstern R, Jakobsson PJ. Human microsomal prostaglandin E synthase-1: purification, functional characterization, and projection structure determination. J Biol Chem. 2003 Jun 20;278(25):22199-209. Epub 2003 Apr 2. PubMed, CrossRef
  61. Tanioka T, Nakatani Y, Semmyo N, Murakami M, Kudo I. Molecular identification of cytosolic prostaglandin E2 synthase that is functionally coupled with cyclooxygenase-1 in immediate prostaglandin E2 biosynthesis. J Biol Chem. 2000 Oct 20;275(42):32775-82. PubMed, CrossRef
  62.  Hayes JD, Flanagan JU, Jowsey IR. Glutathione transferases. Annu Rev Pharmacol Toxicol. 2005;45:51-88. Review. PubMed, CrossRef
  63. Belchik SM, Xun L. S-glutathionyl-(chloro)hydroquinone reductases: a new class of glutathione transferases functioning as oxidoreductases. Drug Metab Rev. 2011 May;43(2):307-16. Epub 2011 Mar 22. Review. PubMed, PubMedCentral, CrossRef
  64. Pabst MJ, Habig WH, Jakoby WB. Glutathione S-transferase A. A novel kinetic mechanism in which the major reaction pathway depends on substrate concentration. J Biol Chem. 1974 Nov 25;249(22):7140-7. PubMed
  65. Guthenberg C, Warholm M, Rane A, Mannervik B. Two distinct forms of glutathione transferase from human foetal liver. Purification and comparison with isoenzymes isolated from adult liver and placenta. Biochem J. 1986 May 1;235(3):741-5. PubMed, PubMedCentral, CrossRef
  66. Danielson UH, Esterbauer H, Mannervik B. Structure-activity relationships of 4-hydroxyalkenals in the conjugation catalysed by mammalian glutathione transferases. Biochem J. 1987 Nov 1;247(3):707-13. PubMed, PubMedCentral, CrossRef
  67. Board PG, Coggan M, Chelvanayagam G, Easteal S, Jermiin LS, Schulte GK, Danley DE, Hoth LR, Griffor MC, Kamath AV, Rosner MH, Chrunyk BA, Perregaux DE, Gabel CA, Geoghegan KF, Pandit J. Identification, characterization, and crystal structure of the Omega class glutathione transferases. J Biol Chem. 2000 Aug 11;275(32):24798-806. PubMed, CrossRef
  68. Guthenberg C, Jensson H, Nyström L, Osterlund E, Tahir MK, Mannervik B. Isoenzymes of glutathione transferase in rat kidney cytosol. Biochem J. 1985 Sep 15;230(3):609-15. PubMed, PubMedCentral, CrossRef
  69. Robinson A, Huttley GA, Booth HS, Board PG. Modelling and bioinformatics studies of the human Kappa-class glutathione transferase predict a novel third glutathione transferase family with similarity to prokaryotic 2-hydroxychromene-2-carboxylate isomerases. Biochem J. 2004 May 1;379(Pt 3):541-52. PubMed, PubMedCentral, CrossRef
  70. Jowsey IR, Thomson RE, Orton TC, Elcombe CR, Hayes JD. Biochemical and genetic characterization of a murine class Kappa glutathione S-transferase. Biochem J. 2003 Jul 15;373(Pt 2):559-69. PubMed, PubMedCentral, CrossRef
  71. Brigelius-Flohé R, Flohé L. Basic principles and emerging concepts in the redox control of transcription factors. Antioxid Redox Signal. 2011 Oct 15;15(8):2335-81. Epub 2011 Apr 5. Review. PubMed, PubMedCentral, CrossRef
  72. Paulson KE, Darnell JE Jr, Rushmore T, Pickett CB. Analysis of the upstream elements of the xenobiotic compound-inducible and positionally regulated glutathione S-transferase Ya gene. Mol Cell Biol. 1990 May;10(5):1841-52. PubMed, PubMedCentral, CrossRef
  73. Reinemer P, Dirr HW, Ladenstein R, Schäffer J, Gallay O, Huber R. The three-dimensional structure of class pi glutathione S-transferase in complex with glutathione sulfonate at 2.3 A resolution. EMBO J. 1991 Aug;10(8):1997-2005. PubMed, PubMedCentral
  74. Wilce MC, Parker MW. Structure and function of glutathione S-transferases. Biochim Biophys Acta. 1994 Mar 16;1205(1):1-18. Review. PubMed, CrossRef
  75. Danielson UH, Mannervik B. Kinetic independence of the subunits of cytosolic glutathione transferase from the rat. Biochem J. 1985 Oct 15;231(2):263-7. PubMed, PubMedCentral, CrossRef
  76. Hegazy UM, Mannervik B, Stenberg G. Functional role of the lock and key motif at the subunit interface of glutathione transferase p1-1. J Biol Chem. 2004 Mar 5;279(10):9586-96. Epub 2003 Dec 15. PubMed, CrossRef
  77. Pemble SE, Taylor JB. An evolutionary perspective on glutathione transferases inferred from class-theta glutathione transferase cDNA sequences. Biochem J. 1992 Nov 1;287 (Pt 3):957-63. PubMed, PubMedCentral, CrossRef
  78. Hayes JD, Clarkson GH. Purification and characterization of three forms of glutathione S-transferase A. A comparative study of the major YaYa-, YbYb- and YcYc-containing glutathione S-transferases. Biochem J. 1982 Dec 1;207(3):459-70.  PubMed, PubMedCentral, CrossRef
  79. Morgenstern R, DePierre JW, Jörnvall H. Microsomal glutathione transferase. Primary structure. J Biol Chem. 1985 Nov 15;260(26):13976-83. PubMed
  80. Arias IM. Liver function from Y to Z. J Clin Invest. 2012 Aug;122(8):2763-4. Review. PubMed, PubMedCentral, CrossRef
  81. Tew KD, Manevich Y, Grek C, Xiong Y, Uys J, Townsend DM. The role of glutathione S-transferase P in signaling pathways and S-glutathionylation in cancer. Free Radic Biol Med. 2011 Jul 15;51(2):299-313. Review.  PubMed, PubMedCentral, CrossRef
  82. De Luca C, Raskovic D, Pacifico V, Thai JC, Korkina L. The search for reliable biomarkers of disease in multiple chemical sensitivity and other environmental intolerances. Int J Environ Res Public Health. 2011 Jul;8(7):2770-97. Review. PubMed, PubMedCentral, CrossRef
  83. Howells RE, Dhar KK, Hoban PR, Jones PW, Fryer AA, Redman CW, Strange RC. Association between glutathione-S-transferase GSTP1 genotypes, GSTP1 over-expression, and outcome in epithelial ovarian cancer. Int J Gynecol Cancer. 2004 Mar-Apr;14(2):242-50. PubMed, CrossRef
  84. LaPensee EW, Schwemberger SJ, LaPensee CR, Bahassi el M, Afton SE, Ben-Jonathan N. Prolactin confers resistance against cisplatin in breast cancer cells by activating glutathione-S-transferase. Carcinogenesis. 2009 Aug;30(8):1298-304. PubMed, PubMedCentral, CrossRef
  85. Laborde E. Glutathione transferases as mediators of signaling pathways involved in cell proliferation and cell death. Cell Death Differ. 2010 Sep;17(9):1373-80. Review. PubMed, CrossRef
  86. Olsen A, Autrup H, Sørensen M, Overvad K, Tjønneland A. Polymorphisms of glutathione S-transferase A1 and O1 and breast cancer among postmenopausal Danish women. Eur J Cancer Prev. 2008 Jun;17(3):225-9. PubMed, CrossRef
  87. Rednam S, Scheurer ME, Adesina A, Lau CC, Okcu MF. Glutathione S-transferase P1 single nucleotide polymorphism predicts permanent ototoxicity in children with medulloblastoma. Pediatr Blood Cancer. 2013 Apr;60(4):593-8. PubMed, PubMedCentral, CrossRef
  88. Franca R, Rebora P, Basso G, Biondi A, Cazzaniga G, Crovella S, Decorti G, Fagioli F, Giarin E, Locatelli F, Poggi V, Valsecchi MG, Rabusin M. Glutathione S-transferase homozygous deletions and relapse in childhood acute lymphoblastic leukemia: a novel study design in a large Italian AIEOP cohort. Pharmacogenomics. 2012 Dec;13(16):1905-16. PubMed, CrossRef
  89. Richiardi L, Fiano V, Grasso C, Zugna D, Delsedime L, Gillio-Tos A, Merletti F. Methylation of APC and GSTP1 in non-neoplastic tissue adjacent to prostate tumour and mortality from prostate cancer. PLoS One. 2013 Jul 9;8(7):e68162. Print 2013. PubMed, CrossRef
  90. Fukushige S, Horii A. DNA methylation in cancer: a gene silencing mechanism and the clinical potential of its biomarkers. Tohoku J Exp Med. 2013;229(3):173-85. Review. PubMed, CrossRef
  91. Turck N, Robin X, Walter N, Fouda C, Hainard A, Sztajzel R, Wagner G, Hochstrasser DF, Montaner J, Burkhard PR, Sanchez JC. Blood glutathione S-transferase-π as a time indicator of stroke onset. PLoS One. 2012;7(9):e43830. PubMed, PubMedCentral, CrossRef
  92. Gauci CG, Jayashi CM, Gonzalez AE, Lackenby J, Lightowlers MW. Protection of pigs against Taenia solium cysticercosis by immunization with novel recombinant antigens. Vaccine. 2012 Jun 6;30(26):3824-8. PubMed, PubMedCentral, CrossRef
  93. Taylor VL, Cummins I, Brazier-Hicks M, Edwards R. Protective responses induced by herbicide safeners in wheat. Environ Exp Bot. 2013 Apr;88(C):93-99. PubMed, PubMedCentral, CrossRef
  94. Kobayashi H, Takase H, Suzuki Y, Tanzawa F, Takata R, Fujita K, Kohno M, Mochizuki M, Suzuki S, Konno T. Environmental stress enhances biosynthesis of flavor precursors, S-3-(hexan-1-ol)-glutathione and S-3-(hexan-1-ol)-L-cysteine, in grapevine through glutathione S-transferase activation. J Exp Bot. 2011 Jan;62(3):1325-36. PubMed, PubMedCentral, CrossRef
  95. Mannervik B. Five decades with glutathione and the GSTome. J Biol Chem. 2012 Feb 24;287(9):6072-83. PubMed, PubMedCentral, CrossRef

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