Ukr.Biochem.J. 2013; Volume 85, Issue 4, Jul-Aug, pp. 61-66


Correlation between base concentration of C-reactive protein in the blood, levels of serum antiendotoxin antibodies and endotoxin-binding capacity of monocytes and granulocytes of healthy people

A. I. Gordienko

State Institution S. I. Georgievsky Crimea State Medical University, Simferopol, Ukraine;

The associative links between base concentration of C-reactive protein (hsCRP), levels of serum antiendotoxin antibodies of different classes and endotoxin-binding capacity of monocytes and granulocytes of healthy volunteers were investigated­ by cluster analysis. In the group of healthy volunteers with increased base concentration of hsCRP in blood the levels of serum antiendotoxin antibodies of different  classes and endotoxin-binding capacity of monocytes and granulocytes were reduced. Thus, the disbalance of detoxification and clearance of  endotoxin by humoral and cellular mechanisms can be one of the possible causes of development of low intensity inflammation and increase of hsCRP concentration in blood.

Keywords: , , ,


  1. Mizuno Y, Jacob RF, Mason RP. Inflammation and the development of atherosclerosis. J Atheroscler Thromb. 2011;18(5):351-8. Review. PubMed, CrossRef
  2. Libby P, Okamoto Y, Rocha VZ, Folco E. Inflammation in atherosclerosis: transition from theory to practice. Circ J. 2010 Feb;74(2):213-20. Review. PubMed, CrossRef
  3. Black S, Kushner I, Samols D. C-reactive Protein. J Biol Chem. 2004 Nov 19;279(47):48487-90. Review. PubMedCrossRef
  4. Bikdeli B. C-reactive protein, statins and the risk of vascular events: a better understanding. Cardiovasc Drugs Ther. 2011 Dec;25(6):545-9. Review. PubMed, CrossRef
  5. Abraham J, Campbell CY, Cheema A, Gluckman TJ, Blumenthal RS, Danyi P. C-reactive protein in cardiovascular risk assessment: a review of the evidence. J Cardiometab Syndr. 2007 Spring;2(2):119-23. Review. PubMed, CrossRef
  6. Stoll LL, Denning GM, Weintraub NL. Endotoxin, TLR4 signaling and vascular inflammation: potential therapeutic targets in cardiovascular disease. Curr Pharm Des. 2006;12(32):4229-45. Review. PubMedCrossRef
  7. Stoll LL, Denning GM, Weintraub NL. Potential role of endotoxin as a proinflammatory mediator of atherosclerosis. Arterioscler Thromb Vasc Biol. 2004 Dec;24(12):2227-36. Review. PubMed, CrossRef
  8. Heine H, Rietschel ET, Ulmer AJ. The biology of endotoxin. Mol Biotechnol. 2001 Nov;19(3):279-96. Review. PubMed, CrossRef
  9. Balzan S, de Almeida Quadros C, de Cleva R, Zilberstein B, Cecconello I. Bacterial translocation: overview of mechanisms and clinical impact. J Gastroenterol Hepatol. 2007 Apr;22(4):464-71. Review. PubMed, CrossRef
  10. Yakovlev MYu.  “Endotoxin Aggression” as a Premorbid State or Universal Pathogenesis Factor of Human and Animal Diseases. Biology Bull Rev. 2003;123(1):31-40.
  11. Gordienko AI. Effect of blood plasma and serum albumin on the specificity of interaction between conjugate lipopolysaccharide-fluorescein isothiocyanate and human peripheral blood leukocytes. J Allerg Clin Immunol. 2008;(2):107-113.
  12. Gordienko AI. New approach to an increase of specificity in determination of antibodies to lipopolysaccharides of Gram-negative bacteria by solid-phase enzyme-linked immunosorbent assay. Ukr Biokhim Zhurn. 2004 Nov-Dec;76(6):130-5. Russian.  PubMed
  13. Zhizhin KS. Medical statistics. Rostov-on-Don: Feniks, 2007. 160p.
  14. Rebrova O.Yu. Statistical analysis of medical data. Application software package STATISTICA. M.: MediaSphera,2002. 312p.
  15. Mandel ID. Cluster analysis. M.: Finansy i statistika, 1988. 176p.
  16. Anand SS, Yusuf S. C-reactive protein is a bystander of cardiovascular disease. Eur Heart J. 2010 Sep;31(17):2092-6. Review. PubMed,CrossRef
  17. Song R, Kim J, Yu D, Park C, Park J. Kinetics of IL-6 and TNF-α changes in a canine model of sepsis induced by endotoxin. Vet Immunol Immunopathol. 2012 Apr 15;146(2):143-9.  PubMed, CrossRef
  18. Jang CH, Choi JH, Byun MS, Jue DM. Chloroquine inhibits production of TNF-alpha, IL-1beta and IL-6 from lipopolysaccharide-stimulated human monocytes/macrophages by different modes. Rheumatology (Oxford). 2006 Jun;45(6):703-10. PubMed, CrossRef
  19. Fitzgerald KA, Rowe DC, Golenbock DT. Endotoxin recognition and signal transduction by the TLR4/MD2-complex. Microbes Infect. 2004 Dec;6(15):1361-7. Review. PubMed, CrossRef
  20. White A, Fletcher TC, Pepys MB. Serum concentrations of C-reactive protein and serum amyloid P component in plaice (Pleuronectes platessa L.) in relation to season and injected lipopolysaccharide. Comp Biochem Physiol B. 1983;74(3):453-8. PubMedCrossRef
  21. Wolter J, Liehr H, Grün M. Hepatic clearance of endotoxins: differences in arterial and portal venous infusion. J Reticuloendothel Soc. 1978 Feb;23(2):145-52. PubMed
  22. Müller-Loennies S, Brade L, Brade H. Neutralizing and cross-reactive antibodies against enterobacterial lipopolysaccharide. Int J Med Microbiol. 2007 Sep;297(5):321-40. Review. PubMed, CrossRef
  23. Hampton RY, Golenbock DT, Penman M, Krieger M, Raetz CR. Recognition and plasma clearance of endotoxin by scavenger receptors. Nature. 1991 Jul 25;352(6333):342-4. PubMedCrossRef
  24. Munford RS, Hall CL. Detoxification of bacterial lipopolysaccharides (endotoxins) by a human neutrophil enzyme. Science. 1986 Oct 10;234(4773):203-5. PubMedCrossRef
  25.  Trautmann M, Held TK, Susa M, Karajan MA, Wulf A, Cross AS, Marre R. Bacterial lipopolysaccharide (LPS)-specific antibodies in commercial human immunoglobulin preparations: superior antibody content of an IgM-enriched product. Clin Exp Immunol. 1998 Jan;111(1):81-90. PubMed, PubMedCentral, CrossRef

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License.