S. A. Babiy¹, T. F. Loskutova², N. I. Shtemenko¹

¹Oles Gonchar Dnipropetrovsk National University, Ukraine;
²Dnipropetrovsk State Medical Acadamy, Ukraine;
e-mail: babiy_s@meta.ua

It was shown that development of the Guerin carcinoma and introduction of cisplatin led to the damage of the kidneys of rats that was confirmed by a relative increase of weight, proteinuria, change of γ-glutamyl transpeptidase and lactate dehydrogenase activity in the urea and tissue homogenates of the kidneys, by a decrease of relative reabsorption and glomerular filtration. Introduction of nanoliposomal forms of the rhenium cluster compounds led to normalization of above mentioned diagnostic indexes and to reduction of the toxic cisplatin influence that was confirmed by biochemical and morphological investigations.

Keywords: antitumor compounds, cisplatin, cluster rhenium compounds, kidneys, nephrotoxicity